Transdermal therapeutic systems: A brief overview of factors affecting penetration and permeation.
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Date
2013-10
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Abstract
The term percutaneous absorption covers the entire process by which a drug applied to the outer surface of the skin is taken up into the systemic
circulation. This requires penetration into the layers of the skin with subsequent permeation across each layer and finally uptake into the capillary blood vessels in
the upper region of the dermis. It is necessary to consider both the structure of the membrane and the interactions of the three components – membrane, penetrant
and vehicle to determine the physical and chemical factors which assist or hinder the process. Not all drug substances are suitable for transdermal delivery. Among
the factors playing a part in percutaneous absorption are the physical and chemical properties of the drug, including its molecular weight, solubility, partition
coefficient, dissociation constant (pKa), the nature of the carrier vehicle, and the condition of the skin. Although general statements applicable to all possible
combinations of drug, vehicle, and skin condition are difficult to draw, most research findings were tried to summarize in this review article.
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Keywords
Factors, Percutaneous absorption, Membrane, Penetrant, Vehicle
Citation
Bhowmick Mithun, Sengodan Tamizharasi, Thangavel Sivakumar. Transdermal therapeutic systems: A brief overview of factors affecting penetration and permeation. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Oct-Nov; 2(6): 636-640.