Effect of pH and sodium ions on intestinal uptake of lysine in rats.

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dc.contributor.authorKaur, Sen_US
dc.contributor.authorBabbar, H Sen_US
dc.contributor.authorMahmood, Aen_US
dc.date.accessioned2009-05-28T15:07:26Z
dc.date.available2009-05-28T15:07:26Z
dc.date.issued1993-06-01en_US
dc.description.abstractIntestinal uptake of lysine in rats progressively decreased with an increase in pH from 5.2 to 8.5, both in the presence and absence of Na+ ions. At pH 5.2 lysine uptake was 30-35% more than that at neutral pH. Na+ activated lysine uptake by 40-50% at pH 5.2 and it was increased to 110-120% at neutral pH. The observed increase in lysine uptake in response to Na+ and H+ gradients was due to enhanced maximal velocity (Vmax), with little change in affinity constant (Kt). Arrhenius analysis revealed a biphasic curve for lysine uptake with transition temperature (Tc) around 20 degrees C (24 degrees C at pH 5.2 in presence of Na+). The energy of activation (Ea) below (16.1-23.4 Kcal/mole) and above (6.7-8.6 Kcal/mole) the Tc was similar at pH 5.2 and 7.0 both in the presence and absence of Na+ ions. The sensitivity of lysine uptake to various inhibitors was also dependent upon pH and Na+ ions.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University, Chandigarh, India.en_US
dc.identifier.citationKaur S, Babbar HS, Mahmood A. Effect of pH and sodium ions on intestinal uptake of lysine in rats. Indian Journal of Experimental Biology. 1993 Jun; 31(6): 529-32en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61584
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArsenites --pharmacologyen_US
dc.subject.meshDinitrophenols --pharmacologyen_US
dc.subject.meshEthylmaleimide --pharmacologyen_US
dc.subject.meshHarmaline --pharmacologyen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshIntestinal Absorption --drug effectsen_US
dc.subject.meshIodoacetates --pharmacologyen_US
dc.subject.meshIodoacetic Aciden_US
dc.subject.meshIsatin --pharmacologyen_US
dc.subject.meshLysine --pharmacokineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSodium --pharmacologyen_US
dc.subject.meshSodium Compounds --pharmacologyen_US
dc.subject.meshSodium-Hydrogen Antiporter --metabolismen_US
dc.titleEffect of pH and sodium ions on intestinal uptake of lysine in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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