AN OBSERVATIONAL STUDY OF PERIPHERAL NEUROPATHY IN DIABETES PATIENTS ON METFORMIN THERAPY AND THE ROLE OF VITAMIN B-12 SUPPLEMENTATION

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dc.contributor.authorPASUPULATI, Hen_US
dc.contributor.authorSWATHI, Ben_US
dc.contributor.authorTAHSEEN, Sen_US
dc.contributor.authorANWER, MSen_US
dc.contributor.authorSANDHYA, Ren_US
dc.contributor.authorFATHIMA, Sen_US
dc.contributor.authorFATIMA, SA.en_US
dc.date.accessioned2025-05-12T07:20:49Z
dc.date.available2025-05-12T07:20:49Z
dc.date.issued2024-12
dc.description.abstractObjective: This study aims to assess the prevalence of peripheral neuropathy in diabetic patients on metformin therapy using the Douleur Neuropathique 4 (DN-4) scale, explore the relationship between long-term metformin use and serum vitamin B-12 levels, and identify how metformin contributes to neuropathy. Additionally, it seeks to raise awareness about the importance of vitamin B-12 monitoring and supplementation for improving patient quality of life. Methods: An observational study was conducted involving diabetes patients on metformin therapy. Data were collected on patient demographics, clinical characteristics, and vitamin B-12 levels. Peripheral neuropathy was assessed using the DN-4 questionnaire. Correlations between metformin duration, dosage, vitamin B-12 levels, and neuropathy prevalence were analyzed. Results: The results indicated that the majority of the study population were male (61.2%) and aged 51-60 years (41.8%), with a majority proportion residing in urban areas (74%). A significant finding was that Peripheral neuropathy was prevalent in 44.8% of patients, with 51.5% exhibiting vitamin B-12 deficiency. Furthermore, the study identified a high prevalence of peripheral neuropathy with a significant correlation between longer metformin use and increased neuropathy (r =0.9372), additionally, a strong negative correlation between metformin dosage and Vitamin B-12 levels (r=-0.9189) highlighted the risk of deficiency with higher doses. Conclusion: The study underscores the critical role of monitoring and supplementing vitamin B-12 in diabetes patients on metformin therapy to mitigate peripheral neuropathy. Regular screening and proactive supplementation could potentially reduce neuropathic complications associated with long-term metformin use.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.affiliationsBharat School of Pharmacy, Mangalpally, Ibrahimpatnam Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Bio Technology, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, Indiaen_US
dc.identifier.citationPASUPULATI H, SWATHI B, TAHSEEN S, ANWER MS, SANDHYA R, FATHIMA S, FATIMA SA.. AN OBSERVATIONAL STUDY OF PERIPHERAL NEUROPATHY IN DIABETES PATIENTS ON METFORMIN THERAPY AND THE ROLE OF VITAMIN B-12 SUPPLEMENTATION . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Dec; 16(12): 21-25en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246452
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber12en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i12.52405en_US
dc.subjectPeripheral neuropathyen_US
dc.subjectdiabetesen_US
dc.subjectmetformin therapyen_US
dc.subjectvitamin B-12 supplementationen_US
dc.subjectvitamin B-12 deficiencyen_US
dc.subjectdosage correlationen_US
dc.subjectmetformin durationen_US
dc.titleAN OBSERVATIONAL STUDY OF PERIPHERAL NEUROPATHY IN DIABETES PATIENTS ON METFORMIN THERAPY AND THE ROLE OF VITAMIN B-12 SUPPLEMENTATIONen_US
dc.typeJournal Articleen_US
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