Antimicrobial effect of platelet‑rich plasma and platelet‑rich fibrin.
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Date
2016-05
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Abstract
Context: Platelet concentrates have been extensively used in a variety of medical fields to promote
soft‑ and hard‑tissue regeneration. The significance behind their use lies in the abundance of
growth factors (GFs) in platelets α‑granules that promote wound healing. Other than releasing
a pool of GFs upon activation, platelets also have many features that indicate their role in the
anti‑infective host defense.
Aim: The aim of this study is to evaluate the antimicrobial activities of platelet‑rich plasma
(PRP) and platelet‑rich fibrin (PRF) against periodontal disease‑associated bacteria.
Subjects and Methods: Blood samples were obtained from ten adult male patients. PRP and PRF
were procured using centrifugation. The antimicrobial activity of PRP and PRF was evaluated
by microbial culturing using bacterial strains of Porphyromonas gingivalis and Aggregatibacter
actinomycetemcomitans.
Results: P. gingivalis and A. actinomycetemcomitans were inhibited by PRP but not by PRF.
Conclusions: PRP is a potentially useful substance in the fight against periodontal pathogens.
This might represent a valuable property in adjunct to the enhancement of tissue regeneration.
Description
Keywords
Antimicrobial effect, blood platelets, platelet‑rich fibrin, platelet‑rich plasma
Citation
Badade Pallavi S, Mahale Swapna A, Panjwani Alisha A, Vaidya Prutha D, Warang Ayushya D. Antimicrobial effect of platelet‑rich plasma and platelet‑rich fibrin. Indian Journal of Dental Research. 2016 May-June; 27(3): 300-304.