Inhibitors of topoisomerases as anticancer drugs: problems and prospects.

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dc.contributor.authorDwarakanath, B Sen_US
dc.contributor.authorKhaitan, Divyaen_US
dc.contributor.authorMathur, Rohiten_US
dc.date.accessioned2009-05-28T11:16:27Z
dc.date.available2009-05-28T11:16:27Z
dc.date.issued2004-07-02en_US
dc.description97 references.en_US
dc.description.abstractDNA topoisomerases, which solve topological problems associated with various DNA transactions, are the targets of many therapeutic agents. Various topoisomerase inhibitors especially, topo-poisons, camptothecin (topo-I) and etoposide (topo-II) are some of the drugs that are used in the current treatment protocols, particularly for the treatment of leukemia (AML, ALL etc). However, tumor resistance, normal and non-specific tissue cytotoxicity are the limitations for successful development of these drugs as one of the primary therapeutic agents for the treatment of tumors in vitro. This brief review presents the current understanding about cytotoxicity development and outlines various approaches to overcome the limitations for enhancing the efficacy of topo-poison based anticancer drugs.en_US
dc.description.affiliationInstitute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Delhi 110054, India. bsd@inmas.orgen_US
dc.identifier.citationDwarakanath BS, Khaitan D, Mathur R. Inhibitors of topoisomerases as anticancer drugs: problems and prospects. Indian Journal of Experimental Biology. 2004 Jul; 42(7): 649-59en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56485
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAntineoplastic Agents --pharmacologyen_US
dc.subject.meshDNA Topoisomerases --antagonists & inhibitorsen_US
dc.subject.meshEnzyme Inhibitors --pharmacologyen_US
dc.subject.meshHumansen_US
dc.titleInhibitors of topoisomerases as anticancer drugs: problems and prospects.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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