Study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation

Simple item page
dc.contributor.authorSelvarju, K.en_US
dc.contributor.authorPrasad, Kondreddi Narayanaen_US
dc.contributor.authorBobba, Ajay Kumar Reddyen_US
dc.date.accessioned2019-12-02T10:08:08Z
dc.date.available2019-12-02T10:08:08Z
dc.date.issued2018
dc.description.abstractBackground: Laryngoscopy and endotracheal intubation, which are a basic and integral part of general anesthesia (GA), are associated with reflex sympathetic stimulation, manifested by tachycardia and hypertension. Aim: The aim was to compare the effect of dexmedetomidine and clonidine on the pressor response among patients undergoing tracheal intubation in elective surgeries under general anesthesia. Materials and methods: A prospective and randomized control study conducted in 80 adult patients of age 18-55 years in ASA I and II were included in this study. Patients were divided into Group D and Group C of 40 patients each. Results: Mean SBP, DBP and MAP in the dexmedetomidine group remained close to the baseline throughout the study period showing a significant difference from clonidine groups following the induction interval. In present study after intubation heart rate, SBP, and DBP was increased in all patients but the increase was more in patients of clonidine group when compared to dexmedetomidine group. There was statistically significant difference in heart rate between the two groups at 1, 3 and 4 min interval after intubation (p value<0.05). No significant changes in peripheral oxygen saturation K. Selvarju, Kondreddi Narayana Prasad, Ajay Kumar Reddy Bobba. Study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation. IAIM, 2018; 5(8): 100-106. Page 101 (SpO2) and cardiac rhythm (ECG) were observed in any patients of both groups. Bradycardia (HR<50/min) was observed in one patient of dexmedetomidine group and two patients in clonidine group, five minutes after intubation. Intraoperative hypotension was observed in one patient of dexmedetomidine group and in two patients of clonidine group. Conclusion: Premedication with dexmedetomidine can safely be recommended for attenuation of provided more stable hemodynamics response to endotracheal intubationen_US
dc.identifier.affiliationsAssociate Professor, Department of Anesthesia, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Anesthesia, Nimra Institute of Medical Sciences, Vijayawada, Andhra Pradesh, India, spinalepidual@gmail.comen_US
dc.identifier.affiliationsAssistant Professor, Department of Community Medicine, Alluri Sitaramaraju Academy of Medical Sciences, Malkapuram, Eluru, Andhra Pradesh, Indiaen_US
dc.identifier.citationSelvarju K., Prasad Kondreddi Narayana, Bobba Ajay Kumar Reddy. Study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation. International Archives of Integrated Medicine. 2018 Aug; 5(8): 107-112en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186911
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber8en_US
dc.relation.volume5en_US
dc.subjectClonidineen_US
dc.subjectDexmedetomidineen_US
dc.subjectPressor responseen_US
dc.subjectEndotracheal intubationen_US
dc.titleStudy between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubationen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
iaim2018v5n8p100.pdf
Size:
798.86 KB
Format:
Adobe Portable Document Format
Download
Collections
International Archives of Integrated Medicine