Chronopharmacology and drug prescribing pattern of physicians in a tertiary care hospital of North India

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dc.contributor.authorSharma, Diwanshuen_US
dc.contributor.authorMalhotra, Pavanen_US
dc.date.accessioned2020-04-23T07:48:48Z
dc.date.available2020-04-23T07:48:48Z
dc.date.issued2018-03
dc.description.abstractBackground: Chronopharmacology is the science dealing with the optimization of drug effects and the minimization of adverse effects by timing medication in relation to the biological rhythm. This concept came into picture to make us understand about periodic and predictable changes in both desired effects and tolerance of medication Chronotherapeutics approach gives more accurate determination of the time when patients are at highest risk and in greatest need of therapy. This Chronopharmacological principle is used in the therapy of various diseases like cardiovascular diseases, allergy and many more. The objective of the study was to analyse whether chronopharmacological approach was being applied in clinical practice by comparing chronopharmacology of 4 drugs to their prescribing pattern by the physicians.Methods: This was observational study where 700 prescriptions written by physicians were audited. To study all the drugs would have been tedious so four commonly used drugs were chosen that is, Proton pump inhibitors, statins, Beta blockers and subcutaneous Insulin.Results: Results showed that chronopharmacological approach has been applied in the clinical field though physician didn’t have clear concept about chronopharmacology and it is relation to the prescribing. Despite this, maximum physician prescribing pattern was comparable to the chronopharmacological data except in case of Proton pump inhibitors.Conclusions: It is concluded that Chronotherapeutics approach gives more accurate determination of the time when patients are at highest risk and in greatest need of therapy. Nevertheless, this variation is only seldom considered by clinicians. If drugs are prescribed by following chronopharmacological approach it can prove beneficial to the patients as more of effectiveness of the drug and lesser side effects.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, Jammu and Kashmir, Indiaen_US
dc.identifier.citationSharma Diwanshu, Malhotra Pavan. Chronopharmacology and drug prescribing pattern of physicians in a tertiary care hospital of North India. International Journal of Basic & Clinical Pharmacology. 2018 Mar; 7(3): 499-502en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199601
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20180664en_US
dc.subjectBeta blockeren_US
dc.subjectChronopharmacolgyen_US
dc.subjectProton pump inhibitorsen_US
dc.subjectPrescribing patternen_US
dc.subjectStatinsen_US
dc.subjectSubcutaneous insulinen_US
dc.titleChronopharmacology and drug prescribing pattern of physicians in a tertiary care hospital of North Indiaen_US
dc.typeJournal Articleen_US
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