Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan.

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dc.contributor.authorHamajima, Nobuyukien_US
dc.contributor.authorRahimov, Bakhodiren_US
dc.contributor.authorMalikov, Yusufen_US
dc.contributor.authorAbdiev, Shavkaten_US
dc.contributor.authorAhn, Keun Sooen_US
dc.contributor.authorBahramov, Saidkarimen_US
dc.contributor.authorKawai, Sayoen_US
dc.contributor.authorNishio, Kazukoen_US
dc.contributor.authorNaito, Marikoen_US
dc.contributor.authorGoto, Yasuyukien_US
dc.date.accessioned2009-05-27T17:36:37Z
dc.date.available2009-05-27T17:36:37Z
dc.date.issued2008-04-21en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractSrc homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) of gastric epithelial cells interacts with cagA from Helicobacter pylori (H. pylori). Our previous studies found the AA genotype of a G/A single nucleotide polymorphism at intron 3 (rs2301756) of PTPN11 gene, which encodes SHP-2, to be associated with a lower risk of gastric atrophy. The present study aimed to examine the association with gastric atrophy among the subjects of a case-control study of peptic ulcer disease (PUD) conducted in the Uzbek Republic. Cases were 95 patients (61 males and 34 females) with PUD aged 16 to 85 years. Controls were 102 hospital volunteers (42 males and 60 females) including 42 patients with miscellaneous diseases, aged 15 to 75 years. Gastric atrophy was evaluated with serum pepsinogens (PG1<70 ng/ml and PG1/PG2<3). Polymorphisms of PTPN11 at intron 3 (rs2301756) and intron10 (rs12229892) were genotyped with PCR with confronting two-pair primers (PCR-CTPP). Anti-cagA IgG antibody was detected in 93.7% of cases and 77.5% in controls. Gastric atrophy was observed in 24.2% of the PUD patients and 33.3% in the controls. The A allele at intron 3 was completely linked to the G allele at intron 10. The age, sex, and group (cases and controls) adjusted odds ratio of gastric atrophy was 0.18 (95% confidence interval, 0.04-0.86) for intron 3 GG genotype relative to AA genotype. Since the finding was opposite to that among Japanese, the H. pylori strains and/or lifestyle in Uzbekistan might modify the association.en_US
dc.description.affiliationDepartment of Preventive Medicine/Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550 Japan. nhamajim@med.nagoya-u.ac.jpen_US
dc.identifier.citationHamajima N, Rahimov B, Malikov Y, Abdiev S, Ahn KS, Bahramov S, Kawai S, Nishio K, Naito M, Goto Y. Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan. Asian Pacific Journal of Cancer Prevention. 2008 Apr-Jun; 9(2): 217-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37511
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis, Atrophic --geneticsen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHelicobacter Infections --complicationsen_US
dc.subject.meshHelicobacter pylori --pathogenicityen_US
dc.subject.meshHumansen_US
dc.subject.meshIntronsen_US
dc.subject.meshJapanen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeptic Ulcer --complicationsen_US
dc.subject.meshPolymorphism, Single Nucleotide --geneticsen_US
dc.subject.meshProtein Tyrosine Phosphatase, Non-Receptor Type 11 --geneticsen_US
dc.subject.meshStomach --metabolismen_US
dc.subject.meshUzbekistanen_US
dc.subject.meshYoung Adulten_US
dc.titleAssociations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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