Effects of Black Seed (Nigella sativa) and Uziza Leaf (Piper guineense) on Electrolytes, Urea and Creatinine of Wistar Albino Rats

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dc.contributor.authorOkoye, Ngozi Francaen_US
dc.contributor.authorIgwiloen_US
dc.contributor.authorElvis, Ikennaen_US
dc.date.accessioned2020-05-05T07:04:22Z
dc.date.available2020-05-05T07:04:22Z
dc.date.issued2019-06
dc.description.abstractAim:For centuries, plant and plant products have played a pivotal role in medication. This study evaluated the effect of aqueous extract of black seed (Nigella sativa) and uziza leaf (Piperguineense)on electrolytes, urea and creatinine of Wistar rats. Materials and Methods:Twenty-five Wistar rats were used for the study; the rats were arranged into five groups with five rats each. Sucrose and margarine were used to induce hyperglycemia and hyperlipidemia respectively on the rats with the exception of the rats in the positive control group. The rats in the negative control were induced using the sucrose and margarine but were not treated using the aqueous extracts. The rats in the uziza group were treated with 2ml of uziza aqueous leaf extract, while the rats in the black seed group were treated with 2ml of black seed aqueous extract. The rats in the black seed & uziza leaf group were treated with 2ml of the combined aqueous extract. Results:The results showed that the extracts had a decreasing effect which was time dependent on the electrolytes. The highest decrease was obtained on the third week of feeding compared to the control (P=.05).The sodium levels (mmol/L) showed for the negative control (198.23 ± 1.96), positive control (108.15 ± 1.60), uziza leaf (98.28 ± 4.17), black seed (101.67 ± 4.24), black seed & uziza (90.83 ± 2.14). The decrease for potassium levels (mEq/L) showed for the negative control (0.90 ± 0.06), positive control (0.05 ± 0.10), uziza leaf (0.07 ± 0.18), black seed (0.06 ± 0.19), black seed & Uziza (0.05 ± 0.10). Furthermore, the extracts also had a reducing effect on urea and creatinine levels with the highest reduction obtained on the third week (p=0.05). The urea levels (mmol/L) showed for the negative control (26.84 ± 0.05), positive control (15.15 ± 1.20), uziza leaf (12.83 ± 0.98), black seed (12.16 ± 2.01), black seed & uziza (11.48 ± 1.78). The extracts also decreased creatinine levels (mmol/L) with the negative control (284.58 ± 0.33), positive control (182.73 ± 3.67), uziza leaf (194.16 ± 18.30), black seed (167.34 ± 14.66), black seed & uziza (174.46 ± 10.66). Conclusion:The extracts significantly decreased the elevated electrolytes levels and therefore uzizaleaf and black seed can be used to restore kidney function.en_US
dc.identifier.affiliationsDepartment of Bichemistry, University of Port Harcourt, Nigeriaen_US
dc.identifier.citationOkoye Ngozi Franca, Igwilo, Elvis Ikenna. Effects of Black Seed (Nigella sativa) and Uziza Leaf (Piper guineense) on Electrolytes, Urea and Creatinine of Wistar Albino Rats . International Journal of Biochemistry Research & Review. 2019 Jun; 26(2): 1-10en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200701
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume26en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2019/v26i230092en_US
dc.subjectCreatinineen_US
dc.subjectelectrolytesen_US
dc.subjectNigella sativaen_US
dc.subjectPiper guineenseen_US
dc.subjectureaen_US
dc.titleEffects of Black Seed (Nigella sativa) and Uziza Leaf (Piper guineense) on Electrolytes, Urea and Creatinine of Wistar Albino Ratsen_US
dc.typeJournal Articleen_US
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