Study On Harmful Effects Of Opium On Liver And Lungs In Chronic Opium Addicts Of Western Rajasthan.
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Date
2011-12
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Abstract
Background: Today opium dependence is widely prevalent in certain states of India, especially
Rajasthan, Punjab, Haryana, Madhya Pradesh (MP) etc. In rural areas of western Rajasthan crude
opium is consumed with a social acceptance by a notable proportion (8.0%) of adult male population.
Later on they become addicted to it. Objective: to observe the changes in some liver and lung function
parameters in opium addicted subjects of Barmer city of Western Rajasthan. Methods:The present
study was conducted in district hospital of Barmer, Rajasthan. Total fifty (50) adult male subjects with
age ranged from 30 to 50 years were participated in this study. Among them 25 were opium addicted
and were considered as study group (Group B) and another 25 apparently healthy adult male of same
age group were designated as control group (Group A). Opium addicts were consuming about 5–11
gm/day opium for >2 years. Then liver function tests were evaluated by estimating serum aspartate
amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase and lung function
tests by measuring FVC, FEV1 , FEV1/FVC% , PEF, FEF 25-75% of both the groups. Results: In this
study AST, ALT and alkaline phosphatase levels were found significantly (p<.05) higher in group B as
compared to those of group A. Again, FVC, FEV1, FEV1/ FVC were significantly (p<.05) lower in group
B as compared to those of group A. PEF (L/sec) and FEF25-75% were also significantly (p<0.001) lower
in group B as compared to those of group A. Conclusion: it is concluded that chronic long term use
of opium, increases the risk of hepatic and pulmonary damage.
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Keywords
Opium addiction, western Rajasthan, LFT, PFT
Citation
Pawan M, Choudhary Raghuveer, Mathur Ranjana, Choudhary M R, Kamla M. Study On Harmful Effects Of Opium On Liver And Lungs In Chronic Opium Addicts Of Western Rajasthan. Journal of Bangladesh Society of Physiologists. 2011 Dec; 6(2): 122-126.