Exploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Rats

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dc.contributor.authorEjike, Onah Christianen_US
dc.contributor.authorFlorence, Onah Chinwemmaen_US
dc.contributor.authorFriday, Ehiaghe Alfreden_US
dc.contributor.authorthanasius, Onyegbule Onyemaen_US
dc.contributor.authorChukwuemeka, Ogbodo Emmanuelen_US
dc.contributor.authorUkamaka, Ijeomah Annen_US
dc.contributor.authorMicheal, Olisah Chineduen_US
dc.contributor.authorSerah, Nnaemeka Wuraolaen_US
dc.contributor.authorChukwuemeka, Meludu Samuelen_US
dc.contributor.authorEmmanuel, Dioka Chudien_US
dc.date.accessioned2024-09-24T06:47:01Z
dc.date.available2024-09-24T06:47:01Z
dc.date.issued2023-06
dc.description.abstractObjective: Lead poisoning is a global public health problem that has beenassociated with poor treatment outcomes. We therefore evaluated the ability of Moringa oleifera (M. oleifera) to reduce blood lead levels (BLL) and lead-induced oxidative stress related to dimercaptosuccinic acid (DMSA) in albino Wister rats. Methods: Thirty rats were assigned to five groups each consisting of six rats. The control group (A) received normal rat chow and water ad libitum for 12 weeks. Group (B-E) initially received 100-mg/kg body weight of lead acetate orally for 6 weeks. Thereafter, groups B, C, D, and E received DMSA and various doses of M. oleifera and their combination for an additional 6 weeks. Blood samples were taken before treatment, 6 and 12 weeks after treatment for analysis of BLL, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferase (GST). Results: BLL and MDA increased significantly (p<0.05), while serum SOD, CAT and GST activities decreased significantly (p<0.05) from their pretreatment valuesafter 6 weeks of lead-acetate administration. However, administration of 400-mg/kg body weight M. oleifera at 12 weeks posttreatment significantly (p<0.05) reduced 6-week BLL by(40.5%); MDA (52%); and significantly (p<0.05) increased the activities of serum SOD by (35%); CAT (26.3%); andGST (53%). Conclusion: M. oleifera was observed not only to be effective in lowering blood lead levels, but also toalleviate lead-induced oxidative stress through enhanced antioxidant activities. M. oleifera may therefore serve asan alternativetherapeutic approach to lead poisoning, particularly in resource-constrained settings.en_US
dc.identifier.affiliationsDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.affiliationsDepartment of Nursing Services, Nnamdi Azikiwe University Teaching Hospital, Nnewien_US
dc.identifier.affiliationsDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaenicology, Federal Medical Centre, Owerrien_US
dc.identifier.affiliationsDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Natural and Applied Sciences, Nasarawa State University Keffien_US
dc.identifier.affiliationsDepartment of Medical Biochemistry, Chukwuemeka Odumegwu Ojukwu University, Uli.en_US
dc.identifier.affiliationsDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.affiliationsDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.affiliationsDepartment of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awkaen_US
dc.identifier.citationEjike Onah Christian, Florence Onah Chinwemma, Friday Ehiaghe Alfred, thanasius Onyegbule Onyema, Chukwuemeka Ogbodo Emmanuel, Ukamaka Ijeomah Ann, Micheal Olisah Chinedu, Serah Nnaemeka Wuraola, Chukwuemeka Meludu Samuel, Emmanuel Dioka Chudi. Exploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Rats. International Journal of Clinical and Biomedical Research. 2023 Apr; 9(2): 1-6en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226858
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://www.sumathipublications.com/index.php/ijcbr/article/view/449/531en_US
dc.subjectAntioxidantsen_US
dc.subjectlead toxicityen_US
dc.subjectMoringa oleiferaen_US
dc.subjectdimercaptosuccinic aciden_US
dc.subjectoxidative stress.en_US
dc.titleExploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Ratsen_US
dc.typeJournal Articleen_US
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