Intratympanic Gentamicin Injection in Ménière’s Disease: Our Ten Years’ Experience and Outcomes
dc.contributor.author | Filosa, Barbara | en_US |
dc.contributor.author | Trusio, Antonio | en_US |
dc.contributor.author | Cristofaro, Generoso De | en_US |
dc.contributor.author | Marra, Pasquale | en_US |
dc.contributor.author | Malafronte, Giuseppe | en_US |
dc.date.accessioned | 2023-08-25T06:43:54Z | |
dc.date.available | 2023-08-25T06:43:54Z | |
dc.date.issued | 2023-03 | |
dc.description.abstract | Objective: The aim of our study is to evaluate the effectiveness of intratympanic gentamicin injection (ITG) on vertigo control with reduced doses and its hearing effects. Materials and Method: The study was conducted at Otolaryngology Department of AORN “S.G. Moscati” between January 2005 and January 2015 on 72 patients with disabling unilateral Meniere’s disease. We use 0.2-0.3 mL of gentamicin sulfate at a concentration of 40mg/ml, injected into the affected ear through the posterior-inferior quadrant of the tympanic membrane. The procedure was carried out for three following days. Main outcome measures: vertigo control and hearing threshold changes after ITG treatment. Results: In 98.6% of the patients(n=71) the ITG produced the full remission of the vertiginous symptoms. In 91.6% of cases(n=66) a single treatment (three consequent injections) was sufficient to control vertigo, in 5.5% of cases(n=4) two treatments were necessary to control vertigo and in 1.3% of patients(n=1) three treatments were necessary to control vertigo. In no case we have had hearing loss after ITG procedure. The pre-treatment pure tone average was 48db. The post-treatment pure tone average was 49.2db. This difference was no statistical difference. Conclusion: In this study we reported high vertigo control, long follow-up and no case of significant hearing worsening. We consider the three injections in the following three days with low doses of gentamicin a safe and valid treatment for Meniere’s disease. | en_US |
dc.identifier.affiliations | Ent Departement A. O “S.G. Moscati”, Avellino. Italy | en_US |
dc.identifier.citation | Filosa Barbara, Trusio Antonio, Cristofaro Generoso De, Marra Pasquale, Malafronte Giuseppe. Intratympanic Gentamicin Injection in Ménière’s Disease: Our Ten Years’ Experience and Outcomes. International Journal of Applied Biology and Pharmaceutical Technology. 2023 Mar; 14(1): 12-15 | en_US |
dc.identifier.issn | 0976-4550 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/225570 | |
dc.language | en | en_US |
dc.publisher | Applied Biology and Pharmaceutical Sciences | en_US |
dc.relation.issuenumber | 1 | en_US |
dc.relation.volume | 14 | en_US |
dc.source.uri | https://www.doi.org/10.26502/ijabpt.202121 | en_US |
dc.subject | Meniere’s disease | en_US |
dc.subject | intratympanic gentamicin injection | en_US |
dc.subject | vertigo control | en_US |
dc.subject | hearing worsening | en_US |
dc.subject | aminoglycoside ototoxicity | en_US |
dc.title | Intratympanic Gentamicin Injection in Ménière’s Disease: Our Ten Years’ Experience and Outcomes | en_US |
dc.type | Journal Article | en_US |
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