A Prospective Randomised Study Comparing Neuromuscular Blockade And Recovery Characteristics Of Two Different Doses Of Cis - Atracurium Versus Atracurium In Elective Surgeries

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dc.contributor.authorK, Sen_US
dc.contributor.authorV, Men_US
dc.contributor.authorB, Sen_US
dc.contributor.authorM, T.en_US
dc.date.accessioned2023-07-14T08:16:26Z
dc.date.available2023-07-14T08:16:26Z
dc.date.issued2022-01
dc.description.abstractBackground:Cisatracurium is the stereoisomer of atracurium but has considerably higher neuromuscular blocking potency, better hemodynamic profile and no association with dose-dependent histamine release, as compared with the parent compound(1)(2,3). On the other hand, 2 ED95dose s of cis-atracurium (100? g/kg) do not create satisfactory intubating conditions such as those seen with equipotent doses of atracurium.There are limited studies which provide us the clarity of a better neuromuscular blocker in terms of intubation and maintainence amongst the two with the most optimum dose. Material And Methods:The study designed as randomised controlled trial, recruited 150 patients into three groups: Group A-atracurium 0.5 mg/kg(2×ED95), Group B and C-cis-atracurium 0.2 mg/kg (4×ED95) and 0.4 mg/kg (8×ED95)respectively and compared them on the basis of onset, duration of action, recovery time, haemodynamic effect and signs of histamine release clinically. Result:Patients in Group C had significantly shorter onset time of block when c ompared with group A & B. Mean duration of block after loading dose was significantly shorter in Group A than group B & C. Group B had a shorter duration of block than C. Recovery time of block in group A was significantly shorter than group B & C. Conclusion:Cis-atracurium in dose of 0.2 mg/kg seems to be better alternative to atracurium 0.5 mg/kg and cis-atracurium 0.4 mg/kg in providing faster onset, intermediate duration of action with fast recovery and it can be used for intubation as well as maintenance.en_US
dc.identifier.affiliationsSenior Resident, Department Of Anaesthesiology, SMS Medical College, Jaipur, 302004, Indiaen_US
dc.identifier.affiliationsPost Graduate, Department Of Anaesthesiology And Critical Care, Dr. S.N. Medical College, Jodhpur, 342003, Indiaen_US
dc.identifier.affiliationsSenior Resident, Department Of General Surgery, J.N.U. Institute For Medical Sciences And Research Centre, Jaipur, 302017, Indiaen_US
dc.identifier.affiliationsSenior Resident, Department Of Anaesthesiology, R.U.H.S College Of Medical Sciences, Jaipur, 302033, Indiaen_US
dc.identifier.citationK S, V M, B S, M T.. A Prospective Randomised Study Comparing Neuromuscular Blockade And Recovery Characteristics Of Two Different Doses Of Cis - Atracurium Versus Atracurium In Elective Surgeries . National Journal of Integrated Research in Medicine. 2022 Jan; 12(6): 26-31en_US
dc.identifier.issn0975-9840
dc.identifier.issn2230 - 9969
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219822
dc.languageenen_US
dc.publisherAssociation of Health Professionals and Health Educatorsen_US
dc.relation.issuenumber6en_US
dc.relation.volume12en_US
dc.source.urihttps://nicpd.ac.in/ojs-/index.php/njirm/article/view/3274en_US
dc.subjectEndotracheal intubationen_US
dc.subjectAtracuriumen_US
dc.subjectCis-atracuriumen_US
dc.titleA Prospective Randomised Study Comparing Neuromuscular Blockade And Recovery Characteristics Of Two Different Doses Of Cis - Atracurium Versus Atracurium In Elective Surgeriesen_US
dc.typeJournal Articleen_US
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