Relationship of chronic periodontitis and plasma C - reactive protein during pregnancy.
Loading...
Date
2016-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Maternal periodontal disease is a chronic oral infection
with local and systemic inflammatory responses and may be
associated with adverse pregnancy outcomes. Elevated levels of Creactive
protein has been linked to adverse pregnancy outcomes in
maternal periodontal disease.
Objectives: To assess plasma C-reactive protein levels in pregnant
women with chronic periodontitis and in periodontal health and to
compare the incidence of preterm delivery in pregnant women
having chronic periodontitis and in periodontal health.
Materials and Methods: A total of 122 pregnant women aged 18
years and above with gestational age < 26 weeks were recruited and
divided into two equal groups (control group, study group) of 61
each. Blood samples were taken from both the groups to determine
the serum C-reactive protein.
Results: The mean value of C-reactive protein levels in subjects
having chronic periodontitis was higher compared to control group
i.e., 2.462±0.318 compared to 1.307±0.361 (P<0.001). The incidence
of preterm delivery (< 37 weeks) was 82% in the chronic periodontitis
group (study group) compared to 3.3% in the control group (P<
0.001). The incidence of low birth weight(<2500g) was 45.9% in
chronic periodontitis (study group) compared to 14.8% in the control
group (p< 0.001).
Conclusion: The findings from the study suggest that periodontal
disease in pregnant women is associated with increased C-reactive
protein levels in pregnancy. Incidence of preterm delivery and low
birth weight infants is higher in pregnant women with chronic periodontitis compared to healthy controls.
Description
Keywords
C-reactive protein, preterm birth, low birth weight
Citation
Navkiran, Kaur A, Singh S, Verma A. Relationship of chronic periodontitis and plasma C - reactive protein during pregnancy. International Journal of Medical and Dental Sciences. 2016 July; 5(2): 1208-1213.