Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress And Inflammation In Rats

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dc.contributor.authorMahmoud, S. M.en_US
dc.contributor.authorKassab, R. B.en_US
dc.contributor.authorMoneim, A. E. A.en_US
dc.date.accessioned2020-09-24T08:01:45Z
dc.date.available2020-09-24T08:01:45Z
dc.date.issued2020-01
dc.description.abstractObjective: The present study was designed to evaluate the effect of zinc oxide nanoparticles (ZnO NPs) on Aluminum chloride (AlCl3)-induced hepato-renal injury.  Methods: Animals were divided into, I-control group; rats received saline, II-AlCl3 group; animals received 100 mg AlCl3/kg body weight, III-ZnO NPs group; rats received 10 mg ZnO NPs/kg body weight, and IV group ZnO NPs+AlCl3. All rats were administered their respective doses daily for 6 w. Hepatorenal function parameters in sera; aminotransferases, bilirubin, urea, and creatinine were estimated. Lipid peroxide level and nitrite\nitrate ratio, glutathione content, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase activities and interleukin-1β, tumor necrosis factor-α levels were determined in both tissues. The histopathological and the immunohistochemical investigations of nuclear factor-kB expression were carried out.  Results: ZnO NPs treatment to AlCl3-intoxicated rats significantly reduced Al accumulation (at p<0.05) in the hepatorenal tissue and increased zinc accumulation (at p<0.05) in liver and kidney, respectively, with respect to AlCl3-group, thus inhibiting oxidative stress and inflammation parameters represented by lipid peroxidation and nitric oxide levels (at p<0.05) compared to AlCl3 group and elevated antioxidant parameters (at p<0.05), compared to AlCl3 treated group, while suppressed interleukin-1β, tumor necrosis factor-α levels (at p<0.05) and the nuclear factor-kB activation in liver and kidney, especially in the kidney if compared to AlCl3-treated group. Hepatorenal function indices indicated significant decreases compared to AlCl3 group (at p<0.05). Conclusion: Results indicated the ameliorative effect of ZnO NPs on aluminum-induced hepato-renal damage.en_US
dc.identifier.affiliationsAssistant Professor of Physiology at Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypten_US
dc.identifier.affiliationsAssistant Professor of Physiology at Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypten_US
dc.identifier.affiliationsProfessor of Physiology at Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypten_US
dc.identifier.citationMahmoud S. M., Kassab R. B., Moneim A. E. A.. Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress And Inflammation In Rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Jan; 12(1): 11-20en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206053
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i1.35956en_US
dc.subjectZinc nanoparticlesen_US
dc.subjectAluminumen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.titleZinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress And Inflammation In Ratsen_US
dc.typeJournal Articleen_US
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