Association Between Neonatal Thyroid Stimulating Hormone Status and Maternal Urinary Iodine Status

Background: Maternal urinary iodine concentration (MUIC) andpercentage of neonates with Thyroid stimulating hormone (TSH)>5 mIU/L are amongst the parameters suggested for assessingadequate iodine status.Objective: To assess the correlation between MUIC andneonatal TSH levels.Study design: Cross-sectional.Settings: Tertiary care center in Delhi, India, between November2015 to November 2016.Participants: Postnatal mother-neonate dyads.Methods: TSH levels assessed among neonatal samples werestratified as below and above 5 mIU/L. MUIC was measured in544 mothers, 400 mother-neonate dyads with neonatal TSHlevels >5 mIU/L (cases) and 144 mother-neonate newbornmother dyads with neonatal TSH <5 mIU/L (controls).Results: The percentage of mothers with iodine insufficiency(9.8% vs 5.6%) as well as iodine excess (54.3% vs 41.7%) weresignificant higher in cases than controls. Mean TSH was alsohigher (P=0.0002) in both the iodine deficient and iodine excessgroup. There was no correlation between neonatal TSH valuesand MUIC.Conclusions: Lack of correlation between neonatal TSH andMUIC is due to iodine excess together with iodine deficiency.

Keywords

Newbornscreening, Postpartum, Povidoneiodine,Pregnant, TSH.

Citation

Sait Haseena, Kapoor Seema, Jindal Ankur, Garg Ritika, Belwal Ravi Shankar, Yadav Sangita, Gupta Sangeeta, Thelma BK. Association Between Neonatal Thyroid Stimulating Hormone Status and Maternal Urinary Iodine Status. Indian Pediatrics. 2019 Jun; 56(6): 472-475

URI

https://imsear.searo.who.int/handle/123456789/199225

Collections

Indian Pediatrics

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