Emerging Markers and Technologies in Urine Sample Validity for Drug Detection: A Brief Review of Detection Methods and Applications

Simple item page
dc.contributor.authorKoujan, AA.en_US
dc.date.accessioned2024-11-30T08:52:06Z
dc.date.available2024-11-30T08:52:06Z
dc.date.issued2024-08
dc.description.abstractUrine sample validity testing is critical in medical diagnostics, forensic investigations, and workplace drug screening to ensure accurate and reliable results. The increasing sophistication of tampering methods, such as adulteration and substitution, necessitates the development of advanced testing techniques. This review explores the latest advancements in urine validity testing, including the integration of machine learning (ML) and artificial intelligence (AI) with high-resolution mass spectrometry (HRMS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These technologies enhance the detection of novel chemical and biological markers, such as unique metabolite profiles, polyglycole patterns, and DNA methylation markers (e.g., TWIST1 and NID2). The identification of new biomarkers and the application of multi-modal analytical approaches provide comprehensive and sensitive detection of tampering. Future directions in the field focus on refining these technologies, ensuring ethical data handling, and expanding regulatory frameworks to protect privacy and enhance the reliability of testing protocols. The advancements discussed promise significant improvements in the detection and prevention of urine sample tampering, ensuring the integrity of testing processes across various applications.en_US
dc.identifier.affiliationsEradah Complex and Mental Health, MOH, Riyadh, KSA and Syrian Board, Damascus University, Laboratory Hematology, Syria.en_US
dc.identifier.citationKoujan AA.. Emerging Markers and Technologies in Urine Sample Validity for Drug Detection: A Brief Review of Detection Methods and Applications. Journal of Advances in Medicine and Medical Research. 2024 Aug; 36(8): 313-322en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237240
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber8en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jammr/2024/v36i85549en_US
dc.subjectUrine sample validityen_US
dc.subjectadulteration detectionen_US
dc.subjectHigh-Resolution Mass Spectrometry (HRMS)en_US
dc.subjectLiquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)en_US
dc.titleEmerging Markers and Technologies in Urine Sample Validity for Drug Detection: A Brief Review of Detection Methods and Applicationsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
jammr2024v36n8p313.pdf
Size:
355.35 KB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Advances in Medicine and Medical Research