Prevalence and Factors Associated at Presence of Central Nervous System Congenital Malformations.

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dc.contributor.authorPorto, Roseane
dc.contributor.authorReis, Francisco Prado
dc.contributor.authorOliveira, Cristiane Costa da Cunha
dc.contributor.authorMelo, Enaldo Vieira de
dc.contributor.authorAragão, José Aderval
dc.date.accessioned2016-12-21T04:54:43Z
dc.date.available2016-12-21T04:54:43Z
dc.date.issued2015
dc.description.abstractIntroduction: Congenital malformations are currently an important cause of morbidity and mortality in many countries, though in most cases their etiology is unknown. The central nervous system (CNS) is involved in many of these defects. Objective: To study the factors associated with CNS congenital malformations and their prevalence in infants born at a high risk maternity hospital in Northeastern Brazil. Materials and Methods: A case-control study performed from January 2010 to December 2011, with data from The Latin American Collaborative Study of Congenital Malformations. Results: Among the 8.405 registered births, 187 were malformed newborns (2.2%). Nervous system malformations were diagnosed in 61 patients (32.6% (CI = 95% 27.5 to 38.0)), the most frequent being neural tube defects and congenital hydrocephaly. Previous history of miscarriage and/or stillbirth (p = 0.008), family history of malformations (p < 0.001) and parental consanguinity (p = 0.028) are associated with CNS malformation. Environmental factors such as maternal chronic diseases, smoking, exposure to teratogenic drugs and alcohol presented no statistically significant differences. Conclusions: The genetic component was an important contributing factor to the etiology of the malformations studied.en_US
dc.identifier.citationPorto Roseane, Reis Francisco Prado, Oliveira Cristiane Costa da Cunha, Melo Enaldo Vieira de, Aragão José Aderval. Prevalence and Factors Associated at Presence of Central Nervous System Congenital Malformations. British Journal of Medicine and Medical Research. 2015; 6(10): 956-964.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/180190
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/metrics/7772en_US
dc.subjectBirth defectsen_US
dc.subjectCentral nervous system malformationsen_US
dc.subjectneural tube defectsen_US
dc.subjectrisk factorsen_US
dc.titlePrevalence and Factors Associated at Presence of Central Nervous System Congenital Malformations.en_US
dc.typeArticleen_US
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