In vitro and In vivo Antitrypanosomal Effects of Petroleum Ether, Chloroform and Methanol Extracts of Artemisia maritima Linn.
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Date
2014-03
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Abstract
Petroleum ether, chloroform and methanol extracts of the whole plant of Artemisia
maritima Linn were studied in vitro and in vivo for antitrypanosomal activity against
Trypanosoma brucei brucei in Swiss albino mice. The extracts were also screened for
phytochemicals/secondary metabolites. All the extracts showed trypanocidal activity
against T. brucei brucei in vitro with the petroleum ether extract showing the highest
activity. The in vivo study revealed that only the chloroform extract A. maritima exhibited
antitrypanosomal activity. This extract at a dose of 100mg/kg body weight significantly
(p<0.05) reduced the parasitemia in T. brucei brucei infected mice when compared with
the other treatment groups. The chloroform extract of A. maritima at this dose reduced the
level of parasitemia to 26%. This reduction in the level of parasitemia is statistically
significant (p<0.05) compared to the other treatment groups and the untreated control
group. The result of the phytochemical analysis revealed that the extracts contain
secondary metabolites like flavonoids, terpenoids, steroids, anthraquinones and alkaloids.
The presence of these secondary metabolites in this plant might be responsible for the
antitrypanosomal activity exhibited by its extracts.
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Keywords
Artemisia maritima, Antitrypanosomal effects, Trypanosoma brucei brucei, In vitro and in vivo studies
Citation
Ene A C, Atawodi S E, Apeh Y E O. In vitro and In vivo Antitrypanosomal Effects of Petroleum Ether, Chloroform and Methanol Extracts of Artemisia maritima Linn. British Journal of Pharmaceutical Research. 2014 Mar; 4(6): 751-758.