Double blind controlled trial of effect of cisapride on gastric emptying in diabetics.

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dc.contributor.authorDutta, Uen_US
dc.contributor.authorPadhy, A Ken_US
dc.contributor.authorAhuja, Ven_US
dc.contributor.authorSharma, M Pen_US
dc.date.accessioned1999-07-01en_US
dc.date.accessioned2009-06-04T04:43:55Z
dc.date.available1999-07-01en_US
dc.date.available2009-06-04T04:43:55Z
dc.date.issued1999-07-01en_US
dc.description.abstractAIMS: Diabetic gastroparesis is a common complication seen in 20-50% of patients due to autonomic neuropathy involving vagal supply. Cisapride, a specific gastrointestinal cholinomimetic agent may thus be effective. METHODS: Fifty-one diabetic patients (age 12-65 years) of disease duration > 5 years were assessed for symptomatic gastroparesis, other diabetic complications and glycemic control. Gastric emptying time (GET) was estimated using a solid meal method (99mTc labeled rice based idli) and patients randomized to receive either cisapride or placebo for a period of 2 weeks. Cisapride was administered in a dose of 10 mg TID. GET and symptom scores were reassessed on the therapy after 2 weeks. RESULTS: Twenty nine of 51 (56.8%) patients had gastroparesis. Mean GET in the gastroparesis group was 141 +/- 66 minutes compared to 24.53 +/- 10 minutes in the non gastroparesis group (p < 0.01). GET decreased by 72% amongst the patients who received cisapride compared to 23% in the placebo group (p < 0.001). Symptom scores also improved in the cisapride group; no adverse effects were noted. CONCLUSIONS: Cisapride improves the symptom score and the solid gastric emptying time in patients suffering from diabetic gastroparesis.en_US
dc.description.affiliationAll India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationDutta U, Padhy AK, Ahuja V, Sharma MP. Double blind controlled trial of effect of cisapride on gastric emptying in diabetics. Tropical Gastroenterology. 1999 Jul-Sep; 20(3): 116-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/125112
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshCisapride --therapeutic useen_US
dc.subject.meshDiabetic Neuropathies --complicationsen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshGastric Emptying --drug effectsen_US
dc.subject.meshGastrointestinal Agents --therapeutic useen_US
dc.subject.meshGastroparesis --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.titleDouble blind controlled trial of effect of cisapride on gastric emptying in diabetics.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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