Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs.

Simple item page
dc.contributor.authorKumar, A K Hemanthen_US
dc.contributor.authorGurumurthy, Premaen_US
dc.date.accessioned2009-05-28T16:06:27Z
dc.date.available2009-05-28T16:06:27Z
dc.date.issued2004-03-06en_US
dc.description.abstractDisposition of uric acid upon administration of ofloxacin (O) alone and in combination with other anti-tuberculosis drugs, rifampicin (R), isoniazid (H) and pyrazinamide (Z) was studied. Twelve male healthy volunteers were investigated on four different occasions with the four drugs alone or in combinations. A partially balanced incomplete block design was adopted and the subjects were randomly allocated to each group. Uric acid concentration in urine samples excreted over 0-8 hr, were determined after coding the samples. There was significant decrease in the group receiving Z when compared to other groups. Though there was a decrease in uric acid excretion in the group receiving O, it was not statistically significant. Rifampicin and H seem to increase the uric acid excretion. The incidence of arthralgia was mainly due to Z and not due to either O or other drugs in the treatment of pulmonary tuberculosis.en_US
dc.description.affiliationTuberculosis Research Centre (ICMR), Chennai 600 031, India. icmrtrc@vsnl.comen_US
dc.identifier.citationKumar AK, Gurumurthy P. Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 323-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62816
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --administration & dosageen_US
dc.subject.meshClinical Trials as Topicen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoniazid --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshOfloxacin --administration & dosageen_US
dc.subject.meshPyrazinamide --administration & dosageen_US
dc.subject.meshRifampin --administration & dosageen_US
dc.subject.meshUric Acid --urineen_US
dc.titleDisposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology