Pattern of adverse drug reactions reported at a tertiary care teaching hospital in northern India

Simple item page
dc.contributor.authorSingh, Arpitaen_US
dc.contributor.authorJain, Atulen_US
dc.contributor.authorSoni, Maneeshen_US
dc.contributor.authorShukla, Poojaen_US
dc.contributor.authorLahon, Joonmonien_US
dc.contributor.authorVerma, Ajay Kumaren_US
dc.date.accessioned2020-04-23T08:01:41Z
dc.date.available2020-04-23T08:01:41Z
dc.date.issued2020-04
dc.description.abstractBackground: Adverse drug reactions (ADRs) are among the leading cause of morbidity and mortality in hospital setup. This study was conducted with the aim of understanding the pattern and occurrence of ADRs to minimize their risk and safeguard public health.Methods: This study is a retrospective analysis of pattern of ADRs reported at ADR monitoring centre (AMC) in a tertiary care hospital. A total of 207 spontaneous ADR reports collected over a period of 18 months were analysed for pattern and type of reactions, demographic profile of patients, organ system affected by ADRs, causative drugs, route of drug administration, severity of reaction, their outcome, management and causality assessment.Results: Most common age group affected by ADRs was 41-50 years with almost equal involvement of male and female gender. Cutaneous reactions involving skin like rashes and itching were most common ADRs. The most common causative drug for ADRs were antimicrobials agents like Penicillin and Cephalosporin group of antibiotics. Orally administered drugs were most commonly involved in causing ADRs. Most of the ADRs belonged to Type A category, were non-serious and moderate in severity. Most of the patients recovered from the ADRs on stopping the suspected drug. On assessing the causality, most of the ADRs were probable with the suspected drugs.Conclusions: Most of the patients recover from ADRs with appropriate and timely intervention, but it is important to understand the pattern and occurrence of ADRs for patient safety and this is possible only with an effective and robust pharmacovigilance system.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsPv Associate, NCC-PvPI, IPC, Ghaziabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh Arpita, Jain Atul, Soni Maneesh, Shukla Pooja, Lahon Joonmoni, Verma Ajay Kumar. Pattern of adverse drug reactions reported at a tertiary care teaching hospital in northern India. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 625-632en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200583
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201189en_US
dc.subjectAdverse drug reactionen_US
dc.subjectAMCen_US
dc.subjectCausality assessmenten_US
dc.subjectPharmacovigilanceen_US
dc.titlePattern of adverse drug reactions reported at a tertiary care teaching hospital in northern Indiaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2020v9n4p625.pdf
Size:
221.82 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology