The Paradigm of Efficacy of Chemotherapy in Association with Different Adjuvant Treatments for Retinoblastoma: A Systematic Review of Literature

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dc.contributor.authorLuz, AFCen_US
dc.contributor.authorAlves, CFen_US
dc.contributor.authorCosta, TNMen_US
dc.contributor.authorAraujo, RHVS deen_US
dc.contributor.authorCoutinho, IJBen_US
dc.contributor.authorLima, VHA.en_US
dc.date.accessioned2024-11-30T08:52:06Z
dc.date.available2024-11-30T08:52:06Z
dc.date.issued2024-08
dc.description.abstractThe treatment of retinoblastoma, the most common malignant eye tumour in children, has considerably evolved with the combination of chemotherapy and adjuvant treatments. This study conducted a systematic literature review to analyse the effectiveness of chemotherapy associated with different adjuvant therapies, such as thermotherapy, cryotherapy, and immunotherapy, in controlling retinoblastoma. Through a comprehensive search strategy in electronic databases, relevant studies published to date were identified and selected. The inclusion criteria were rigorously applied to ensure the relevance of the selected articles. The qualitative and quantitative analysis of the extracted data revealed patterns and trends regarding the effectiveness of these therapeutic combinations. The results indicated that integrating chemotherapy with adjuvant treatments significantly improved clinical outcomes, promoting better vision preservation and reducing recurrence rates. However, variability in treatment response and the need for an individualised approach were highlighted as fundamental factors for therapeutic success. This systematic review reinforced the importance of a multimodal approach and continuous research to improve therapeutic strategies in the treatment of retinoblastoma, pointing to the need for future investigations that can consolidate and innovate clinical practices in this field.en_US
dc.identifier.affiliationsPará University Center, Brazilen_US
dc.identifier.affiliationsPará University Center, Brazilen_US
dc.identifier.affiliationsPará University Center, Brazil and João Barros Barreto University Hospital, Brazilen_US
dc.identifier.affiliationsPará University Center, Brazil , Vallinoto Clinic, Brazil and Outpatient and Specialized Unit of The Municipality of Barcarena, Brazilen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Federal University of Pará, Brazilen_US
dc.identifier.affiliationsUniversidade Federal do Pará, Brazil and Independent Researcher, ONE Company, Brazil.en_US
dc.identifier.citationLuz AFC, Alves CF, Costa TNM, Araujo RHVS de, Coutinho IJB, Lima VHA.. The Paradigm of Efficacy of Chemotherapy in Association with Different Adjuvant Treatments for Retinoblastoma: A Systematic Review of Literature. Journal of Advances in Medicine and Medical Research. 2024 Aug; 36(8): 255-271en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237236
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber8en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jammr/2024/v36i85545en_US
dc.subjectAdjuvant treatmentsen_US
dc.subjectchemotherapyen_US
dc.subjectcryotherapyen_US
dc.subjectimmunotherapyen_US
dc.subjectretinoblastomaen_US
dc.subjectsystematic reviewen_US
dc.subjectthermotherapyen_US
dc.titleThe Paradigm of Efficacy of Chemotherapy in Association with Different Adjuvant Treatments for Retinoblastoma: A Systematic Review of Literatureen_US
dc.typeJournal Articleen_US
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