Involvement of potassium channels in hypoglycemic effect of sertraline.

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dc.contributor.authorKhanam, Raziaen_US
dc.contributor.authorPillai, K Ken_US
dc.date.accessioned2009-05-28T13:03:16Z
dc.date.available2009-05-28T13:03:16Z
dc.date.issued2006-02-17en_US
dc.description.abstractEffect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.en_US
dc.description.affiliationDepartment of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India. rkhanam@jamiahamdard.ac.inen_US
dc.identifier.citationKhanam R, Pillai KK. Involvement of potassium channels in hypoglycemic effect of sertraline. Indian Journal of Experimental Biology. 2006 Feb; 44(2): 120-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58901
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6363/1/IJEB%2044%282%29%20120-122.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDiabetes Mellitus, Experimental --chemically induceden_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshGlucose --analysisen_US
dc.subject.meshHyperglycemia --chemically induceden_US
dc.subject.meshHypoglycemic Agents --pharmacologyen_US
dc.subject.meshMuscle Relaxation --drug effectsen_US
dc.subject.meshPinacidil --pharmacologyen_US
dc.subject.meshPotassium Channels --physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSertraline --pharmacologyen_US
dc.subject.meshStreptozocinen_US
dc.subject.meshSulfonylurea Compounds --pharmacologyen_US
dc.subject.meshVasodilation --drug effectsen_US
dc.subject.meshVasodilator Agents --pharmacologyen_US
dc.titleInvolvement of potassium channels in hypoglycemic effect of sertraline.en_US
dc.typeJournal Articleen_US
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