Utilisation of antimicrobial agents in intensive care unit at a tertiary care teaching hospital in eastern India

dc.contributor.authorPanda, Rajendra Kumaren_US
dc.contributor.authorAbhisek, P. Ansumanen_US
dc.contributor.authorSika, Lalit Mohanen_US
dc.contributor.authorPradhan, Shweta Supriyaen_US
dc.contributor.authorRoutray, Sidharth Srabanaen_US
dc.contributor.authorHazra, Srikanta Mohantyen_US
dc.date.accessioned2020-04-23T07:58:05Z
dc.date.available2020-04-23T07:58:05Z
dc.date.issued2019-09
dc.description.abstractBackground: Antimicrobial agents (AMAs) are the most frequently used drugs in the intensive care units (ICU) and regular auditing can prevent the development of resistance to AMAs, reduce the cost and incidence of adverse drug reactions. The present study was conducted to assess the drug utilisation pattern by measuring the defined daily dose (DDD) per 100 bed days for the AMAs used and their correlation with the APACHE score II.Methods: This was a prospective observational study, conducted in the Central ICU of SCB Medical College and Hospital, Cuttack, Odisha for 4 months. Data regarding demographic profile, diagnosis, APACHE II score, microbiologic investigation, length of stay, outcome and utilisation pattern of AMAs assessing anatomic therapeutic chemical (ATC) classification and measuring the antimicrobial consumption index (ACI) equal to DDD per 100 bed days were collected and subjected to descriptive analysis. Multinomial logistic regression model was used to predict probabilities of different possible outcomes of categorically distributed variables and independent variables.Results: Mean age of study population was 44.70±14.814 with male and female ratio of 1.63:1. Septicaemia was the most common cause of admission. AMAs were prescribed to 92.66% of patients during their stay which constitutes 37.32% of the total drugs used. The DDD per 100 bed days for the AMAs were 118.59 and ceftriaxone was found to be most frequently used. Patients having higher APACHE II score received more no of AMAs (4.20±1.30). Patients having low APACHE II Scores received less number of antibiotics as compared to patients having higher score.Conclusions: AMAs were prescribed to 92.66% patients in the central ICU and there is significant relation between the APACHE II score and number of AMAs prescribed.en_US
dc.identifier.affiliationsDepartment of Pharmacology, S.C.B. Medical College, Cuttacken_US
dc.identifier.affiliationsDepartment of Pharmacology, MKCGMCH, Berhampuren_US
dc.identifier.affiliationsDepartment of Pharmacology, Hi-Tech Medical College, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, DHH, Khurda Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Anaesthesiology and Crictical Care, SCBMCH, Cuttack, Odisha, Indiaen_US
dc.identifier.citationPanda Rajendra Kumar, Abhisek P. Ansuman, Sika Lalit Mohan, Pradhan Shweta Supriya, Routray Sidharth Srabana, Hazra Srikanta Mohanty. Utilisation of antimicrobial agents in intensive care unit at a tertiary care teaching hospital in eastern India. International Journal of Basic & Clinical Pharmacology. 2019 Sep; 8(9): 1951-1958en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200340
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20193672en_US
dc.subjectIntensive care uniten_US
dc.subjectUtilisation patternen_US
dc.subjectAntimicrobial agentsen_US
dc.subjectAnatomic therapeutic chemical classificationen_US
dc.subjectDDD per 100 bed daysen_US
dc.subjectAPACHE II scoreen_US
dc.titleUtilisation of antimicrobial agents in intensive care unit at a tertiary care teaching hospital in eastern Indiaen_US
dc.typeJournal Articleen_US
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