Safety of oral graded challenges as a diagnostic approach hypersensitivity reaction to anti-tuberculosis drugs: a case report
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Date
2022-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Tuberculosis (TB) still becomes a significant health problem in developing countries, especially in Indonesia. Allergy to antitubercular drugs is a real hindrance to the management of TB. The first-line anti-TB drug (ATD) is still the most effective TB drug, but it can have some side effects. One of these side effects is drug hypersensitivity reactions (DHR) which can affect a patient's compliance. The recommended diagnostic approach to DHR is a graded challenge by introducing drugs safely and optimally under a threshold dose until the usual daily dose is reached. We present a case of DHR to ATB drug and oral graded challenge as the diagnosis approach.
Description
Keywords
Graded challenges, Safety, DHR
Citation
Dwipayana Putu Aditya, Suryana Ketut. Safety of oral graded challenges as a diagnostic approach hypersensitivity reaction to anti-tuberculosis drugs: a case report. International Journal of Advances in Medicine. 2022 Dec; 9(12): 1203-1206