Cytotoxicity Activity and Phytochemical Screening of Anthocleista djalonensis Root Extracts against Cancer Cells

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dc.contributor.authorOkoro, Ijeoma Solomonen_US
dc.contributor.authorTor-Anyiin, Terrumum Amomen_US
dc.contributor.authorIgoli, John Ogbajien_US
dc.contributor.authorKhan, Muluh Emmanuelen_US
dc.date.accessioned2020-01-02T06:14:28Z
dc.date.available2020-01-02T06:14:28Z
dc.date.issued2019-03
dc.description.abstractAim: Several medicinal uses have been reported for Anthocleista djalonensis and many types of pure compounds have been isolated. However, the anti-cancer activity of this plant has not been proven. The aim of this study was to screen for the phytochemicals present in the rootn-hexane, ethyl acetate, and acetone extracts of Anthocleista djalonensis, and to evaluate its anticancer potential against human cervix adenocarcinoma cells (HeLa cells) in vitro. Place and Duration of Study: The study was carried out in Department of Organic Chemistry, Rhodes University, Grahamstown, South Africa. The duration period was between March and July, 2016. Methodology: Extracts were prepared by soaking the root powder in the respective solvents with continuous stirring; The extracts were filtered and evaporated to remove the solvents. The extracts were then screened for phytocompounds by preliminary screening methods. Anti-cancer potential was carried out by a Resazurin assay and CC50 values were determined. Results: The extracts showed the presence of carbohydrates, glucoside, alkaloids, flavonoids, terpenoids, tannins, saponins, sterols. All extracts demonstrated moderate cytotoxicity against HeLa cells. Conclusion: The hexane, ethyl acetate and acetone extracts showed anticancer property. The roots extracts of Anthocleista djalonesis were thus found to possess potential anticancer activities.en_US
dc.identifier.affiliationsDepartment of Chemistry, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue State, Nigeria.en_US
dc.identifier.affiliationsDepartment of Chemistry, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue State, Nigeria.en_US
dc.identifier.affiliationsDepartment of Chemistry, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue State, Nigeria.en_US
dc.identifier.affiliationsDepartment of Chemistry, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue State, Nigeria.en_US
dc.identifier.citationOkoro Ijeoma Solomon, Tor-Anyiin Terrumum Amom, Igoli John Ogbaji, Khan Muluh Emmanuel. Cytotoxicity Activity and Phytochemical Screening of Anthocleista djalonensis Root Extracts against Cancer Cells. European Journal of Medicinal Plants. 2019 Mar; 27(2): 1-7en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189475
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume27en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2019/v27i230108en_US
dc.subjectAnthocleista djalonensisen_US
dc.subjectanticanceren_US
dc.subjectcytotoxicityen_US
dc.subjectHeLa cellsen_US
dc.subjectphytochemicalsen_US
dc.subjectResazurin assayen_US
dc.titleCytotoxicity Activity and Phytochemical Screening of Anthocleista djalonensis Root Extracts against Cancer Cellsen_US
dc.typeJournal Articleen_US
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