Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.

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dc.contributor.authorKulkarni, Shrinivas Ken_US
dc.contributor.authorPatil, Chandrashekhar Sen_US
dc.contributor.authorJain, Naveen Ken_US
dc.contributor.authorSingh, Amarjiten_US
dc.date.accessioned2009-05-28T16:24:01Z
dc.date.available2009-05-28T16:24:01Z
dc.date.issued2004-06-21en_US
dc.description.abstractBiliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of smooth muscle. Diclofenac, in varying concentration (9.4 x 10(-5) mol/l and 14.1 x 10(-5) mol/l) shifted the concentration response curve of acetylcholine to the right without suppressing the maximal response. However, in higher concentration diclofenac (18.9 x 10(-5) mol/l) blocked the response in an unsurmountable fashion. Further, analgin (11.09 x 10(-5), 16.63 x 10(-5) and 22.18 x 10(-5) mol/l) in equimolar concentrations did not alter the concentration response curve of acetylcholine, but in higher concentration analgin (44.36 x 10(-5) mol/l) also blocked the response in an unsurmountable fashion. Pitofenone (2.5 x 10(-6) mol/l) also, shifted the concentration response curve of acetylcholine to right in a parallel fashion with no change in maximal response. The present study confirms the potent antispasmodic activity of diclofenac-pitofenone combination in comparison to analgin-pitofenone in molar equivalent concentration (in comparison to diclofenac) against acetylcholine-induced contractions of guinea pig ileum.en_US
dc.description.affiliationPharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India. skpu@yahoo.comen_US
dc.identifier.citationKulkarni SK, Patil CS, Jain NK, Singh A. Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm. Indian Journal of Experimental Biology. 2004 Jun; 42(6): 567-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63185
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetylcholine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --pharmacologyen_US
dc.subject.meshBenzophenones --pharmacologyen_US
dc.subject.meshCholinergic Agents --metabolismen_US
dc.subject.meshDiclofenac --pharmacologyen_US
dc.subject.meshDipyrone --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleum --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshParasympatholytics --pharmacologyen_US
dc.subject.meshSpasm --drug therapyen_US
dc.titleModulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.en_US
dc.typeJournal Articleen_US
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