Griseofulvine: BCS Classification and Solubility Enhancement Techniques.

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dc.contributor.authorMarvania, Akshay
dc.contributor.authorDeshpande, Ashwini
dc.date.accessioned2013-09-17T06:20:10Z
dc.date.available2013-09-17T06:20:10Z
dc.date.issued2012-08
dc.description.abstractThe BCS is a scientific system for classifying drug substance based upon their aqueous solubility as related to dose and permeability. The BCS is guiding for prediction of in vivo performance of the drug substance in new drug discovery and lead optimization due to the dependence of drug absorption and pharmacokinetics propertoes. The solubility behaviour of drugs remains one of the most challenging in formulation development. Due to poor aqueous solubility of BCS Class II result in the poor oral bioavailability makes drug formulation development more difficult. Hence, various approaches have been developed with a focus on enhancement of the solubility, dissolution rate, and oral bioavailability of poorly water-soluble drugs. Present article overview the concept of Biopharmaceutical classification systems (BCS), Biopharmaceutical Drug Disposition Classification System (BDDCS) & recent classification for solubility enhancement of poorly water soluble drugs. The article also reviews various efforts taken for solubility enhancement of Gresiofulvine using various techniques from 1996 to 2012.en_US
dc.identifier.citationMarvania Akshay, Deshpande Ashwini. Griseofulvine: BCS Classification and Solubility Enhancement Techniques. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Aug-Sept; 1(3): 112-121.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148319
dc.language.isoenen_US
dc.source.urihttps://www.ijrdpl.com/newcurrentissue_aug_sept/36.pdfen_US
dc.subjectSolubilityen_US
dc.subjectDissolutionen_US
dc.subjectBioavailabilityen_US
dc.subjectGriseofulvineen_US
dc.titleGriseofulvine: BCS Classification and Solubility Enhancement Techniques.en_US
dc.typeArticleen_US
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