Effect of Donepezil and Vitamin B12Supplement on Serum Thyroid Profile in Alzheimer’s Disease

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dc.contributor.authorYeram, Neelamen_US
dc.contributor.authorDalvi, Shubhangi M.en_US
dc.contributor.authorPatil, Vinayak W.en_US
dc.contributor.authorKale, Vinayak P.en_US
dc.contributor.authorJagiasi, Kamleshen_US
dc.contributor.authorAbichandani, Leela G.en_US
dc.date.accessioned2020-10-16T08:45:59Z
dc.date.available2020-10-16T08:45:59Z
dc.date.issued2020-01
dc.description.abstractAims: The aim of this study was to investigate thyroid status in Alzheimer’s Disease (AD) patients and its response to donepezil and vitamin B12supplement therapy for 6 months.Design:Case-Control Observational study.Place and Duration:Department of Biochemistry, GGMC & Sir J. J. Group of Hospitals, Mumbai, India between March 2017 and July 2019.Methodology:Case-Control study comprised of 71 AD patients and 70 healthy controls above 60 years of age. Blood serum samples were analyzed forthyroid hormones levels by the chemiluminescence method. AD patients weretreated with donepezil (5mg/day) and vitamin B12supplement (1.5mg/day) and thyroid profile was observed at intervals of 3 and 6 months. Statistical evaluationwas done by using IMB SPSS statistics version 25.Results:Serum levels of thyroid hormones were low in euthyroidAD patients when compared with controls at the baseline level [T3 (120.64 ± 20.64 vs127.8 ± 17.29), T4 (7.71 ± 2.34 vs 7.54 ± 1.85), FT3 (1.2 ± 0.13 vs 2.26 ± 0.63) and FT4 (0.79 ± 0.08 vs 1.29 ± 0.27)]except TSH which was increased in AD [TSH (2.71 ± 1.19 vs 2.34 ± 0.65)]. During follow-ups at 3 and 6 months, there was a slight decrease in TSH levels in response to the therapy.Conclusion: The AD patients were euthyroid with low T3, FT3 and FT4 serum levels and high TSH serum levels. Thyroid hormones might play a role as markers for disease progression. Donepezil and vitamin B12therapy could not benefit restorethe normal thyroid functioning in a period of 6 months. Further longitudinal research with larger cohort might help in elucidating thyroid dysfunction in AD and develop novel therapeutic strategies.en_US
dc.identifier.affiliationsDepartment of Biochemistry, GGMC and Sir J. J. Group of Hospitals, Mumbai, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, GGMC and Sir J. J. Group of Hospitals, Mumbai, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Vedantaa Medical College, Vedantaa Hospital and Research Centre, Dahanu, India.en_US
dc.identifier.affiliationsDepartment of Psychiatry, GGMC and Sir J. J. Group of Hospitals,Mumbai, India.en_US
dc.identifier.affiliationsDepartment of Neurology, GGMC and Sir J. J. Group of Hospitals, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, GGMC and Sir J. J. Group of Hospitals, Mumbai, India.en_US
dc.identifier.citationYeram Neelam, Dalvi Shubhangi M., Patil Vinayak W., Kale Vinayak P., Jagiasi Kamlesh, Abichandani Leela G.. Effect of Donepezil and Vitamin B12Supplement on Serum Thyroid Profile in Alzheimer’s Disease. International Neuropsychiatric Disease Journal. 2020 Jan; 13(2): 1-8en_US
dc.identifier.issn2321-7235
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209753
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume13en_US
dc.source.urihttps://dx.doi.org//10.9734/INDJ/2019/v13i230108en_US
dc.subjectThyroid stimulating hormoneen_US
dc.subjectAlzheimer’s Diseaseen_US
dc.subjectdonepezilen_US
dc.subjectvitamin B12en_US
dc.titleEffect of Donepezil and Vitamin B12Supplement on Serum Thyroid Profile in Alzheimer’s Diseaseen_US
dc.typeJournal Articleen_US
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