Adverse drug reaction profile and prescription pattern of antihypertensive drug monotherapy at tertiary care hospital Nepalgunj, Nepal

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dc.contributor.authorNeupane, Ganesh Prasaden_US
dc.contributor.authorRai, Mayaen_US
dc.date.accessioned2020-04-23T07:47:37Z
dc.date.available2020-04-23T07:47:37Z
dc.date.issued2018-01
dc.description.abstractBackground: Hypertension is the leading cause of morbidity and mortality worldwide which requires long term therapy to prevent complication associated with it. As drugs are used for longer duration it is necessary to know potential undesirable effects for making the appropriate choice. Aim and objective of the study was to monitor the adverse drug reactions (ADRs) and to know prescribing pattern of antihypertensive monotherapy.Methods: The present work was an open, non-comparative, observational study conducted on seventy-three (73) hypertensive patients who were prescribed single antihypertensive drug at medical OPD of Nepalgunj Medical college by conducting patient interviews, recording the data on ADR monitoring form.Results: Calcium channel blockers were found to be the most frequently associated drugs with adverse drug reactions (n=12), followed by diuretics (n= 6), Angiotensin converting enzyme inhibitors (n=3), ?-blockers (n= 2) and Angiotensin receptor blocker (n=1). Among individual drugs, amlodipine was found to be the commonest drug associated with adverse drug reactions (n = 10). On analysis of prescription pattern again amlodipine was most commonly prescribed antihypertensive monotherapy followed by hydrochlorothiazide.Conclusions:Amlodipine was most commonly associated with ADRs and it was also most commonly prescribed antihypertensive drugs as monotherapy. The above findings would be useful for physicians in rational prescribing.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Nepalgunj Medical College, Chisapani, Banke, Nepalen_US
dc.identifier.affiliationsDepartment of Microbiology, Nepalgunj Medical College, Chisapani, Banke, Nepalen_US
dc.identifier.citationNeupaneGanesh Prasad, RaiMaya. Adverse drug reaction profile and prescription pattern of antihypertensive drug monotherapy at tertiary care hospital Nepalgunj, Nepal. International Journal of Basic & Clinical Pharmacology. 2018 Jan; 7(1): 75-79en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199526
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20175678en_US
dc.subjectAdverse drug reactionen_US
dc.subjectAntihypertensive agentsen_US
dc.subjectPrescription patternen_US
dc.titleAdverse drug reaction profile and prescription pattern of antihypertensive drug monotherapy at tertiary care hospital Nepalgunj, Nepalen_US
dc.typeJournal Articleen_US
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