Evaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats.

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dc.contributor.authorNathiya, S
dc.contributor.authorNandhini, A
dc.date.accessioned2014-12-17T11:24:17Z
dc.date.available2014-12-17T11:24:17Z
dc.date.issued2014-03
dc.description.abstractBackground: Aluminum is present in several manufactured foods and medicines and is also used in water purifi cation. It is known that aluminum induces an oxidative stress characterized by an increase in lipid peroxidation and depletion of antioxidants. Therefore, the present experiment was undertaken to determine the effectiveness of hydroalcoholic extract of root bark of Salacia oblonga (SOHE) in modulating the aluminum chloride (AlCl3) induced oxidative stress in rats. Methods: Animals were assigned into four groups: control; AlCl3 300 mg/kg b.w.; Salacia 67 mg/kg; AlCl3 (300 mg/kg b.w.) plus Salacia (67 mg/kg b.w.), respectively. Rats were orally administered their respective doses daily for 36 days. The effect of these treatments in infl uencing the aluminum induced biochemical changes on liver, kidney, lungs, and heart were studied. Result: The results showed that S. oblonga produced signifi cant (p<0.05) reduction of malondialdehyde, while the activities of superoxide dismutase, reduced glutathione, glutathione S-transferase and catalase were positively modulated. Conclusion: Our data demonstrated that S. oblonga protects against aluminuminduced oxidative stress, which is an important fi nding that further reinforces the antioxidant properties of this natural product.en_US
dc.identifier.citationNathiya S, Nandhini A. Evaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats. International Journal of Basic & Clinical Pharmacology. 2014 Mar-Apr; 3(2): 315-319.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154004
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=149537en_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidanten_US
dc.subjectAluminum chlorideen_US
dc.subjectSalacia oblongaen_US
dc.titleEvaluation of antioxidant effect of Salacia oblonga against aluminum chloride induced visceral toxicity in albino rats.en_US
dc.typeArticleen_US
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