Antinociceptive action of FK506 in mice.

Simple item page
dc.contributor.authorSingh, Amanpreeten_US
dc.contributor.authorKumar, Gauraven_US
dc.contributor.authorNaidu, Pattipati Sen_US
dc.contributor.authorKulkarni, Shrinivas Ken_US
dc.date.accessioned2009-05-28T14:49:42Z
dc.date.available2009-05-28T14:49:42Z
dc.date.issued2003-12-24en_US
dc.description.abstractImmunophilins are abundantly present in the brain as compared to the immune system. Immunophilin-binding agents like FK506 are known to inactivate neuronal nitric oxide synthase (nNOS) by inhibiting calcineurin and decrease the production of nitric oxide. Nitric oxide is involved in the mediation of nociception at the spinal level. In the present study, the effect of FK506 on the tail flick response in mice and the possible involvement of NO-L-arginine pathway in this paradigm was evaluated. FK506 (0.5, 1 and 3 mg/kg, ip) produced a significant antinociception in the tail flick test. Nitric oxide synthase (NOS) inhibitor L-NAME significantly and dose dependently (10-40 mg/kg, ip) potentiated the FK506 (0.5 mg/kg)-induced antinociception. On the other hand, NOS substrate L-arginine (100, 200 and 400 mg/kg) inhibited the FK506-induced antinociception in a dose-dependent manner. Concomitant administration of L-NAME (20 and 40 mg/kg) with L-arginine (200 mg/kg) blocked the inhibition exerted by L-arginine on the FK506-induced antinociception. Thus, it was concluded that NO- L-arginine pathway may be involved in the FK506-induced antinociception in tail flick test.en_US
dc.description.affiliationPharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.en_US
dc.identifier.citationSingh A, Kumar G, Naidu PS, Kulkarni SK. Antinociceptive action of FK506 in mice. Indian Journal of Experimental Biology. 2003 Dec; 41(12): 1405-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61209
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnalgesics --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNitric Oxide --physiologyen_US
dc.subject.meshTacrolimus --pharmacologyen_US
dc.titleAntinociceptive action of FK506 in mice.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology