Renal Protective Effect of Ginkgo biloba and L-carnitine Extracts against Pentylenetetrazol Induced Toxicity, Oxidative Stress, Injury and Proliferation Alternation in Epileptic Rats

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dc.contributor.authorTousson, Ehaben_US
dc.contributor.authorKeshta, Akaber T. H.en_US
dc.contributor.authorHussein, Youssefen_US
dc.contributor.authorFekry, Reda M.en_US
dc.contributor.authorAbo-Ghaneima, Wafaa K.en_US
dc.date.accessioned2019-12-06T09:19:09Z
dc.date.available2019-12-06T09:19:09Z
dc.date.issued2019-06
dc.description.abstractObjectives: Ginkgo biloba leaf extract (GBLE) and L-carnitine extract are a commercial product used as a nutraceutic herbal widely. They have antioxidant and reactive oxygen species (ROS) scavenger. This study hypothesized that GB and L-carnitine may have protective effects against pentylenetetrazol (PTZ) induced oxidative damage in kidney in male albino rats. Materials and Methods: A total of 80 male albino rats were equally divided into eight groups (G1, control; G2, GBLE; G3, L-carnitine; G4, Pentylenetetrazole; G5&G6, pre and post treated PTZ with L-carnitine groups respectively; G7&G8, pre and post treated PTZ with GBLE respectively). Results: Serum urea, creatinine, uric acid and cystatin c were significantly increased in PTZ group when compared with control. Also; kidney homogenate MDA and DNA fragmentation were increased when compared with control while, significant decrease in CAT, SOD, GST and TAC in PTZ when compared with control. On other hand pre and post-treatment with L-carnitine and GBLE improved these parameters. Conclusions: The results revealed that; the treatment with L-carnitine improved these parameters more than GBLE and the results of post treatment were better than pre-treatment.en_US
dc.identifier.affiliationsDepartment of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.en_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt.en_US
dc.identifier.affiliationsDepartment of Anatomy and Embryology, Faculty of Medicine, Mutah University, Jordan and Department of Anatomy Faculty of Medicine, Zagazig University, Egypt.en_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt.en_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt.en_US
dc.identifier.citationTousson Ehab, Keshta Akaber T. H., Hussein Youssef, Fekry Reda M., Abo-Ghaneima Wafaa K.. Renal Protective Effect of Ginkgo biloba and L-carnitine Extracts against Pentylenetetrazol Induced Toxicity, Oxidative Stress, Injury and Proliferation Alternation in Epileptic Rats. Annual Research & Review in Biology. 2019 Jun; 32(2): 1-13en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188065
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/arrb/2019/v32i230076en_US
dc.subjectPentylenetetrazoleen_US
dc.subjectGinkgo bilobaen_US
dc.subjectL-carnitineen_US
dc.subjectoxidative stressen_US
dc.subjectDNA damageen_US
dc.subjectkidney ratsen_US
dc.titleRenal Protective Effect of Ginkgo biloba and L-carnitine Extracts against Pentylenetetrazol Induced Toxicity, Oxidative Stress, Injury and Proliferation Alternation in Epileptic Ratsen_US
dc.typeJournal Articleen_US
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