Micronodular thymoma with lymphoid stroma: As benign as it sounds
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Date
2025-03
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Wolters Kluwer - Medknow
Abstract
Micronodular thymoma (MNT) is a rare subtype of thymoma (reported incidence is approximately 1–5%). We report a case received as a core biopsy from the “right lung mass” of a 31?year?old female. CT scan showed an 8.1 cm large well?defined mass lesion in the right middle lobe, causing indentation and mild compression of the right atrium. Microscopically, the biopsy showed a thymic neoplasm comprised of multiple discrete and coalescing nodules of bland epithelioid tumor cells separated by an epithelial cell?free lymphocyte?rich stroma. On immunohistochemistry, cytokeratin highlighted the thymic epithelial cells. The lymphoid cells showed a naive T?cell phenotype (TdT+ CD 3+). It is worthwhile recognizing this rare variant of thymoma as almost all the patients present with localized low stage disease with rare/no reports of recurrences or distant metastases.
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Keywords
Lung mass, micronodular, thymoma
Citation
Chaudhary K, Gala R, Mehta J. Micronodular thymoma with lymphoid stroma: As benign as it sounds. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 216-218