Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract.

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dc.contributor.authorRaphael, K Regien_US
dc.contributor.authorSabu, Mcen_US
dc.contributor.authorKumar, Kb Harien_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2009-05-27T17:35:53Z
dc.date.available2009-05-27T17:35:53Z
dc.date.issued2006-04-15en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractChemopreventive activity of Phyllanthus amarus Schum & Thonn (Euphorbiaceae) extract was studied with regard to N-methyl N'-nitro-N-nitrosoguanidine (MNNG) induced stomach cancer in Wistar rats. Administration of the extract with MNNG significantly reduced the incidence of gastric neoplasms in rats (44%) as well as their numbers. Moreover, elevated levels of enzymes in the stomach were found to be reduced by P. amarus administration. For example, gamma-glutamyl transpeptidase activity was decreased from 20.3 +/- 6.7 mmol/min/mg protein to almost normal levels (2.8 +/- 0.9) by 750 mg/kg body weight of the extract. Similarly glutathione S-transferase activity (1317.6 +/- 211 n mol/min/mg protein) and glutathione reductase (368 +/- 66) levels in the MNNG treated group were found to be lowered to 494.8 +/- 76 and 192 +/- 45, respectively, while reduced glutathione (GSH) was increased from 4.6+/- 0.9 to 8.5+/-1.4 n mol/min/mg protein. AgNOR dots and clusters, indicators of cellular proliferation, which were increased by MNNG treatment, became near to normal in P. amarus treated animals.en_US
dc.description.affiliationAmala Cancer Research Centre, Thrissur, Kerala 680 555, India.en_US
dc.identifier.citationRaphael KR, Sabu M, Kumar KH, Kuttan R. Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pacific Journal of Cancer Prevention. 2006 Apr-Jun; 7(2): 299-302en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37485
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGastric Mucosa --enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylnitronitrosoguanidineen_US
dc.subject.meshPhyllanthusen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Components, Aerialen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStomach Neoplasms --chemically induceden_US
dc.titleInhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract.en_US
dc.typeJournal Articleen_US
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