Antibacterial Activity of Nigella Sativa Linn. Seeds Against Multiple Antibiotics Resistant Clinical Strains of Staphylococcus aureus

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dc.contributor.authorSalman, Mohammad Tariqen_US
dc.contributor.authorKhan, Rahat Alien_US
dc.contributor.authorShukla, Induen_US
dc.date.accessioned2019-11-16T07:25:37Z
dc.date.available2019-11-16T07:25:37Z
dc.date.issued2016-07
dc.description.abstractObjective: Staphylococcus aureus is one of the major resistant pathogens extremely adaptable to antibiotic pressure. Nigella sativa (black cumin) seed extracts and essential oil have been shown to possess antimicrobial activity against several bacteria but little work has been done on their effect against multidrug resistant S. aureus strains isolated from patients. So, we studied antibacterial activity of Nigella sativa against multidrug resistant clinical strains of Staphylococcus aureus. It was an experimental, in vitro study. Materials and methods: Nigella sativa (black cumin) seed essential oil and extracts were tested in varying dilutions against 40 clinical strains of Staphylococcus aureus which were isolated from patients attending a tertiary care teaching hospital in North India using disc agar diffusion technique on inoculated Muellar Hinton agar plates under standard laboratory conditions. The tested strains were resistant to 4 or more clinically used antibiotics belonging to at least 3 different classes. Results: The Methanolic extract and oil of Nigella sativa were found active against 38 and 35 multi-drug resistant strains respectively. Both the oil and Methanolic extract showed remarkable dose dependant antibacterial activity against the tested strains up to a dilution of 1:50 as evident from the zones of inhibition. Conclusion: Nigella sativa possesses antibacterial activity against multidrug resistant clinical strains of Staphylococcus aureusen_US
dc.identifier.affiliationsDepartment of Pharmacology, College of Medicine, University of Dammam, King Faisal Coastal Road, Dammam, Eastern Province, Saudi Arabia. 31441. P.O. Box 1982.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India. 202002.en_US
dc.identifier.affiliationsDepartment of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India. 202002.en_US
dc.identifier.citationSalman Mohammad Tariq, Khan Rahat Ali, Shukla Indu. Antibacterial Activity of Nigella Sativa Linn. Seeds Against Multiple Antibiotics Resistant Clinical Strains of Staphylococcus aureus. International Archives of BioMedical and Clinical Research. 2016 Jul-Sep; 2(3): 96-99en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184328
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume2en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2016.2.3.24en_US
dc.subjectNigella sativaen_US
dc.subjectBlack seeden_US
dc.subjectBlack cuminen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntibiotic resistanceen_US
dc.titleAntibacterial Activity of Nigella Sativa Linn. Seeds Against Multiple Antibiotics Resistant Clinical Strains of Staphylococcus aureusen_US
dc.typeJournal Articleen_US
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