Study of association between expression of E-cadherin and Autocrine Motility Factor in different grades of Colorectal adenocarcinoma

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dc.contributor.authorBurman, Debashis Royen_US
dc.contributor.authorDutta, Sujit Kumaren_US
dc.contributor.authorDhar, Indranilen_US
dc.date.accessioned2019-12-02T10:09:24Z
dc.date.available2019-12-02T10:09:24Z
dc.date.issued2018
dc.description.abstractThough incidence of Colorectal carcinoma is relatively less in consideration of world wide data, Indian scenario differs in higher incidence of Grade 3 carcinoma with signet ring cell component. We tried to find association between intercellular adhesion and propagation of cancer cell in Adenocarcinoma of Colorectal region. E-cadherin (ECAD) is the strongest intercellular adhesion molecule of epithelial cells and Autocrine Motility Factor (AMFR) is known propagator of cancer cell. We studied simultaneous immunohistochemical expression of these two molecules in 92 already diagnosed cases that were treated surgically by Colectomy or Abdomino Pelvic Resection. Normal Colorectal mucosa reacted strongly with ECAD and weakly with AMFR. With increasing dedifferentiation of the tumor, reversal manifested- more aggressive grades showed varied expression in comparison to its less aggressive type. Gastric 3 adenocarcinoma show weak ECAD (83% vs. 35%) and more AMFR (93% vs. 35%) expression in comparison to Grade 1. Weak ECAD and strong AMFR was also associated with increase in depth of tumor invasion. As ECAD and AMFR is at least partially responsible for varying histologic grade and behavioral pattern of colorectal adenocarcinoma, simultaneous evaluation of both parameters is helpful to understand pathway of progression of such cancer cell.en_US
dc.identifier.affiliationsProfessor, Department of Laboratory Oncology (Oncopathology), Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsCA to The Mayor of Bidhannagar Municipal Corporation, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Dept. of Laboratory Medicine, Calcutta School of Tropical Medicine, India, indranildhar629@gmail.comen_US
dc.identifier.citationBurman Debashis Roy, Dutta Sujit Kumar, Dhar Indranil. Study of association between expression of E-cadherin and Autocrine Motility Factor in different grades of Colorectal adenocarcinoma. International Archives of Integrated Medicine. 2018 Nov; 5(11): 19-27en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187083
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber11en_US
dc.relation.volume5en_US
dc.subjectColorectal carcinomaen_US
dc.subjectE- cadherinen_US
dc.subjectAutocrine Motility factor Receptoren_US
dc.titleStudy of association between expression of E-cadherin and Autocrine Motility Factor in different grades of Colorectal adenocarcinomaen_US
dc.typeJournal Articleen_US
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