Development and Validation of UV Spectrophotometric Method for the Estimation of Haloperidol.

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dc.contributor.authorYasir, Mohd.
dc.contributor.authorSara, U V S
dc.date.accessioned2015-09-14T10:58:22Z
dc.date.available2015-09-14T10:58:22Z
dc.date.issued2014-06
dc.description.abstractAims: The aim of the present work was to develop and validate a sensitive, simple, accurate, precise & cost effective UV spectrophotometric method for the estimation of haloperidol in prepared pharmaceutical formulations of solid lipid nanoparticles. Methodology: The different analytical performance parameters such as linearity, range, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization (ICH) Q2 (R1) guidelines. The study was performed in phosphate buffer of pH 7.4. Results: The peak (λmax) of haloperidol appeared at a wavelength of 247.5 nm in phosphate buffer (pH 7.4). Beer-Lambert’s law was obeyed in the concentration range of 2–20 μg/ml with correlation coefficient (R2) 0.9994. Conclusion: The results of the study demonstrated that the developed procedure was accurate, precise and reproducible, while being simple, cheap and less time consuming. Therefore, this method can be suitably applied for the estimation of haloperidol in prepared solid lipid nanoparticles.en_US
dc.identifier.citationYasir Mohd, Sara U V S. Development and Validation of UV Spectrophotometric Method for the Estimation of Haloperidol. British Journal of Pharmaceutical Research. 2014 June; 4(11): 1407-1415.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163452
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/4752en_US
dc.subjectAntipsychoticen_US
dc.subjecthaloperidolen_US
dc.subjectstabilityen_US
dc.subjectUV spectrophotometric methoden_US
dc.subjectvalidationen_US
dc.titleDevelopment and Validation of UV Spectrophotometric Method for the Estimation of Haloperidol.en_US
dc.typeArticleen_US
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