Low dose fentanyl attenuates hypertension but not tachycardia duringlaryngoscopy and trachealintubation in a three arm study.

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dc.contributor.authorKumar, VAen_US
dc.contributor.author, Vaddineni, Jen_US
dc.contributor.authorChavali, Nen_US
dc.date.accessioned2019-12-02T09:50:49Z
dc.date.available2019-12-02T09:50:49Z
dc.date.issued2016
dc.description.abstractBackground: Tracheal intubation may induce; hypertension, tachycardia, and/or arrhythmia. Fentanyl is a frequently used opioid that joins with hypnotic agents to diminish hemodynamic responses to tracheal intubation. Furthermore, lidocaine has a suppressive effect on the circulatory responses in patients undergoing laryngoscopy and tracheal intubation. However, intravenous lignocaine has shown variable results and large doses of fentanyl causes hypotension and cough. We compared the effectiveness of intravenous lignocaine 1.5 mg/kg bolus and intravenous fentanyl 2 mcg/kg bolus in attenuating the sympathetic response to laryngoscopy and tracheal intubation. Materials and methods: One hundred and fifty ASA physical status I or II patients undergoing elective, non-cardiac procedures were randomized, to one of the three treatments such as either normal saline or lignocaine 2 mg/kg or fentanyl 2 mcg/kg. Intubation was carried out 3 minutes after administration of these study drugs. Patients received Midazolam before induction, and Thiopental, Rocuronium during anesthesia. The heart rate, blood pressure and SPO2 were recorded a day before (B), before intubation (0) at 1 2 3 4-5 minutes after induction. Results: Tachycardia (HR>100 beats/min) after intubation was statistically similar across 85% (17/20), 75% (15/20) and 55% (11/20) saline, lignocaine, and fentanyl respectively (p>0.05). Hypertension (SBP > 180 mmHg) was seen in 80% (16/20), 70% (14/20) and 40% (8/20) with saline, Valluri Anil Kumar, Vaddineni Jagadish, Netra Chavali. Low dose fentanyl attenuates hypertension but not tachycardia during laryngoscopy and tracheal intubation in a three arm study. IAIM, 2016; 3(4): 72-77. Page 73 lignocaine and fentanyl respectively. The incidence of hypertension with fentanyl was significantly (p<0.05) lower than saline; however, such a meaning was not observed with lignocaine. Conclusion: Low dose of fentanyl prevented hypertension but not tachycardia as compared to normal saline; on the other hand, lignocaine did not attenuate cardiovascular responses during laryngoscopy and tracheal intubation.en_US
dc.identifier.affiliationsAssistant Professor, Department of Anesthesia, Narayana Medical College, Nellore, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Anesthesia, Narayana Medical College, Nellore, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsSenior Resident, Department of Anesthesia, Bollineni Super Specialty Hospital (KIMS), Nellore, India, author email: aniljyoin@gmail.comen_US
dc.identifier.citationKumar VA, Vaddineni J, Chavali N. Low dose fentanyl attenuates hypertension but not tachycardia duringlaryngoscopy and trachealintubation in a three arm study. International Archives of Integrated Medicine. 2016 Apr; 3(4): 72-77en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186150
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber4en_US
dc.relation.volume3en_US
dc.subjectFentanylen_US
dc.subjectLignocaineen_US
dc.subjectLaryngoscopyen_US
dc.subjectIntubationen_US
dc.subjectAttenuation of cardiovascular responsesen_US
dc.titleLow dose fentanyl attenuates hypertension but not tachycardia duringlaryngoscopy and trachealintubation in a three arm study.en_US
dc.typeJournal Articleen_US
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