COVID-19 in Children with West Syndrome: An Ambispective Study

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dc.contributor.authorMadaan, Priyankaen_US
dc.contributor.authorSaini, Lokeshen_US
dc.contributor.authorDhir, Poojaen_US
dc.contributor.authorBhagwat, Chandanaen_US
dc.contributor.authorGoel, Mallikaen_US
dc.contributor.authorSoni, Akshitaen_US
dc.contributor.authorSahu, Jitendra Kumaren_US
dc.contributor.authorVikas, Sahilen_US
dc.date.accessioned2023-08-19T04:53:38Z
dc.date.available2023-08-19T04:53:38Z
dc.date.issued2023-08
dc.description.abstractObjectives To study the course of West syndrome (WS) and coronavirus disease-19 (COVID-19) in children with WS who contracted SARS-CoV-2 infection. Methods This ambispective study was conducted at a tertiary-care center in North India between December 2020 and August 2021 after approval from the Institute Ethics Committee. Five children with WS, positive for COVID-19 based on RT-PCR, fulflled the inclusion criteria. Results One child with COVID-19 during the frst wave was retrospectively included while four children (of the 70 children screened) were prospectively enrolled. The median age at onset of epileptic spasms was 7 mo (2 boys), and that at presentation with COVID-19 was 18.5 mo. Three had underlying acquired structural etiology. Three were in remission following standard therapy, while two had ongoing spasms at the time of COVID-19 illness. During the illness, two of those in remission continued to be in remission while one child had a relapse. The children with ongoing epileptic spasms had variable course [one had persistent spasms and other had transient cessation lasting 3 wk from day 2 of COVID-19 illness, but electroencephalography (on day 8 of COVID-19 illness) continued to show hypsarrhythmia]. Fever was the most typical symptom (and sometimes the only symptom) of COVID-19, with a duration ranging from 1–8 d. Two children had moderate COVID-19 illness requiring hospitalization, while the rest had a mild illness. All the afected children had complete recovery from COVID-19. Conclusion The severity of COVID-19 illness in children with WS is often mild, while the subsequent course of WS is variable.en_US
dc.identifier.affiliationsPediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, PGIMER, Chandigarh, Indiaen_US
dc.identifier.citationMadaan Priyanka, Saini Lokesh, Dhir Pooja, Bhagwat Chandana, Goel Mallika, Soni Akshita, Sahu Jitendra Kumar, Vikas Sahil. COVID-19 in Children with West Syndrome: An Ambispective Study. Indian Journal of Pediatrics. 2023 Aug; 90(8): 754–760en_US
dc.identifier.issn0973-7693
dc.identifier.issn0019-5456
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223763
dc.languageenen_US
dc.publisherDr. K C Chaudhuri Foundationen_US
dc.relation.issuenumber8en_US
dc.relation.volume90en_US
dc.source.urihttps://doi.org/10.1007/s12098-022-04201-4en_US
dc.subjectInfantile spasms syndromeen_US
dc.subjectInfantile spasmsen_US
dc.subjectEpileptic spasmsen_US
dc.subjectChildren with epilepsyen_US
dc.subjectCoronavirus disease 2019en_US
dc.titleCOVID-19 in Children with West Syndrome: An Ambispective Studyen_US
dc.typeJournal Articleen_US
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