COVID-19 in Children with West Syndrome: An Ambispective Study
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Date
2023-08
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. K C Chaudhuri Foundation
Abstract
Objectives To study the course of West syndrome (WS) and coronavirus disease-19 (COVID-19) in children with WS who contracted SARS-CoV-2 infection. Methods This ambispective study was conducted at a tertiary-care center in North India between December 2020 and August 2021 after approval from the Institute Ethics Committee. Five children with WS, positive for COVID-19 based on RT-PCR, fulflled the inclusion criteria. Results One child with COVID-19 during the frst wave was retrospectively included while four children (of the 70 children screened) were prospectively enrolled. The median age at onset of epileptic spasms was 7 mo (2 boys), and that at presentation with COVID-19 was 18.5 mo. Three had underlying acquired structural etiology. Three were in remission following standard therapy, while two had ongoing spasms at the time of COVID-19 illness. During the illness, two of those in remission continued to be in remission while one child had a relapse. The children with ongoing epileptic spasms had variable course [one had persistent spasms and other had transient cessation lasting 3 wk from day 2 of COVID-19 illness, but electroencephalography (on day 8 of COVID-19 illness) continued to show hypsarrhythmia]. Fever was the most typical symptom (and sometimes the only symptom) of COVID-19, with a duration ranging from 1–8 d. Two children had moderate COVID-19 illness requiring hospitalization, while the rest had a mild illness. All the afected children had complete recovery from COVID-19. Conclusion The severity of COVID-19 illness in children with WS is often mild, while the subsequent course of WS is variable.
Description
Keywords
Infantile spasms syndrome, Infantile spasms, Epileptic spasms, Children with epilepsy, Coronavirus disease 2019
Citation
Madaan Priyanka, Saini Lokesh, Dhir Pooja, Bhagwat Chandana, Goel Mallika, Soni Akshita, Sahu Jitendra Kumar, Vikas Sahil. COVID-19 in Children with West Syndrome: An Ambispective Study. Indian Journal of Pediatrics. 2023 Aug; 90(8): 754–760