TCF7L2 gene variant rs7903146 affects the risk of Type 2 Diabetes by modulating incretin secretion

Simple item page
dc.contributor.authorChandrasekaran, Shanmugapriyaen_US
dc.contributor.authorGopinath, Poonguzhalien_US
dc.date.accessioned2019-12-02T10:11:19Z
dc.date.available2019-12-02T10:11:19Z
dc.date.issued2019
dc.description.abstractBackground: Type2 diabetes mellitus (T2DM) is a highly inheritable disease. Transcription factor 7- like 2 (TCF7L2) gene regulates the expression of glucagon-like peptide 1 (GLP-1) in L cells of small intestine. GLP1 plays a critical role in blood glucose homeostasis by stimulating postprandial insulin secretion and increasing insulin sensitivity. Aim of the study: TCF7L2 gene variants may affect the susceptibility to Type 2 diabetes by altering GLP-1 levels. Materials and methods: This case-control study was conducted with 90 newly diagnosed patients with Type2 diabetes mellitus as cases and 90 age and sex-matched healthy volunteers as controls. TCF7L2 rs7903146 genotyping was done and we also estimated Fasting and postprandial GLP -1 level, Fasting and Postprandial insulin level and calculated HOMA-IR in both cases and controls. Results: Out study showed that T+ genotype, lower fasting GLP-1 level and lower postprandial GLP1 levels were more observed among cases as compared to controls. Low mean GLP 1 activity, high Mean HOMA-IR, low postprandial insulin, low percentage rise in insulin were observed among T+ genotype than among T- genotypic individuals. Conclusion: Hence, the study concludes that T+ genotype causes a decrease in GLP-1 levels, which in turn by decreasing postprandial insulin levels and by increasing insulin resistance increases the risk of Type2 diabetes.en_US
dc.identifier.affiliationsAssociate Professor, Department of Biochemistry, Government Medical College, Omandurar Govt. Estate, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Biochemistry, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India, poonguzhalig@gmail.comen_US
dc.identifier.citationChandrasekaran Shanmugapriya, Gopinath Poonguzhali. TCF7L2 gene variant rs7903146 affects the risk of Type 2 Diabetes by modulating incretin secretion. International Archives of Integrated Medicine. 2019 Mar; 6(3): 95-98en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187261
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber3en_US
dc.relation.volume6en_US
dc.subjectGliptinsen_US
dc.subjectGLP-1en_US
dc.subjectIncretinsen_US
dc.subjectPolymorphismen_US
dc.subjectType 2 diabetesen_US
dc.subjectTCF7L2en_US
dc.subjectrs7903146en_US
dc.titleTCF7L2 gene variant rs7903146 affects the risk of Type 2 Diabetes by modulating incretin secretionen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
iaim2019v6n3p83.pdf
Size:
1.02 MB
Format:
Adobe Portable Document Format
Download
Collections
International Archives of Integrated Medicine