Exploring the Correlation Between Fibrinogen-to-Albumin Ratio and Contrast-Induced Nephropathy in the Study Population
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Date
2024-01
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Publisher
Society for Health Care & Research Development
Abstract
Background: Contrast-Induced Nephropathy (CIN) presents a significant risk in non-ST elevation acute coronary syndrome (NSTE-ACS) patients undergoing percutaneous coronary intervention (PCI). This study investigates the association between the Fibrinogen-to-Albumin Ratio (FAR) and CIN in such patients. Material & Methods: This cross-sectional study was conducted at the Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, from June 2019 to May 2020. 200 NSTE-ACS patients undergoing PCI were categorized into two groups based on FAR: Group I (FAR ? 0.106, n=100) and Group II (FAR < 0.106, n=100). Clinical parameters, including pulse rate, blood pressure, and biochemical markers, were analyzed. The incidence of CIN and the role of FAR as a predictive marker were statistically evaluated. Results: Baseline clinical parameters showed no significant differences between the groups, with pulse rates averaging 88.8�.4 bpm in Group I and 87.7�.4 bpm in Group II (p=0.62). Troponin I levels were higher in Group I (42.1�.6 ng/dl) compared to Group II (35.5�.6 ng/dl, p=0.07). Group I also exhibited higher hemoglobin levels (12.5�5 gm/dl vs. 12.0�5 gm/dl in Group II, p=0.02). The incidence of CIN was significantly higher in Group I at 12%, compared to 2% in Group II. FAR was identified as a significant predictor of CIN, with an odds ratio of 11.45 (p=0.006). Conclusions: The study establishes FAR as a significant independent predictor of CIN in NSTE-ACS patients undergoing PCI. These findings suggest that FAR can be an effective biomarker for assessing CIN risk, potentially guiding more tailored patient management strategies in this high-risk group.
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Keywords
Fibrinogen-to-Albumin Ratio (FAR), Contrast-Induced Nephropathy (CIN), Biomarkers, Cardiovascular
Citation
Mridha Sohel, Rashid Md. Mamunur, Kundu Samir, Momen Abdul, Afroza Nahid, Masum Mahmudul Hasan, Alam Iftekhar. Exploring the Correlation Between Fibrinogen-to-Albumin Ratio and Contrast-Induced Nephropathy in the Study Population. Annals of International Medical and Dental Research. 2024 Jan; 10(1): 50-61