Conjugate formation between effector and target as a function of cytotoxicity in antibody-dependent killing of AK-5 tumor.

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dc.contributor.authorKausalya, Sen_US
dc.contributor.authorPardhasaradhi, B Ven_US
dc.contributor.authorManogaran, P Sen_US
dc.contributor.authorKhar, Aen_US
dc.date.accessioned2009-05-28T14:13:17Z
dc.date.available2009-05-28T14:13:17Z
dc.date.issued1995-03-01en_US
dc.description.abstractThe present study was carried out to mechanistically view a possible correlation between the process of, conjugate formation and its relation to target cell death. AK-5 killing is mediated by CD8+ natural killer cells through ADCC. Immune effectors on exposure to antibody primed AK-5 tumor cells formed tight conjugates. Ability of various cell types (NK, T, monocytes and macrophages) to form conjugates was evaluated. Marked increase in the number of NK cells binding to the target as compared to the other cell types was observed. Cytotoxicity of free and bound effectors against antibody tagged AK-5 cells demonstrated a reduced cytotoxic ability of the former in contrast to a significantly high lytic potential of the bound effectors. The results highlight the requirement for priming of NK cells which mediate killing of AK-5 tumor and provide additional evidence that formation of stable conjugates acts as the first signal for triggering lymphocyte activation and effective target cell lysis.en_US
dc.description.affiliationCentre for Cellular and Molecular Biology, Hyderabad, India.en_US
dc.identifier.citationKausalya S, Pardhasaradhi BV, Manogaran PS, Khar A. Conjugate formation between effector and target as a function of cytotoxicity in antibody-dependent killing of AK-5 tumor. Indian Journal of Experimental Biology. 1995 Mar; 33(3): 161-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60427
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonal --immunologyen_US
dc.subject.meshAntibody-Dependent Cell Cytotoxicityen_US
dc.subject.meshCell Death --immunologyen_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHistiocytic Disorders, Malignant --immunologyen_US
dc.subject.meshKiller Cells, Natural --immunologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleConjugate formation between effector and target as a function of cytotoxicity in antibody-dependent killing of AK-5 tumor.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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