Breast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast India

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dc.contributor.authorZodinpuii, Den_US
dc.contributor.authorPautu, JLen_US
dc.contributor.authorZothankima, Ben_US
dc.contributor.authorKhenglawt, Len_US
dc.contributor.authorLallawmzuali, Den_US
dc.contributor.authorLalmuanpuii, Ren_US
dc.contributor.authorzuali, Len_US
dc.contributor.authorRalte, Len_US
dc.contributor.authorMuthukumaran, RBen_US
dc.contributor.authorVarma, AKen_US
dc.contributor.authorZothanzama, Jen_US
dc.contributor.authorSenthil, Kumar, N.en_US
dc.date.accessioned2023-06-27T06:31:19Z
dc.date.available2023-06-27T06:31:19Z
dc.date.issued2022-09
dc.description.abstractBackground: High incidence of breast cancer among the endogamous Mizo-Mongoloid tribe stresses the need to explore the disease pertaining to the family history as well as other risk factors. This study in-vestigates the association of risk factors and inherited diseases with breast cancer.Methodology: The study includes 426 unrelated breast cancer cases and 810 healthy controls of female Mizo ethnicity. Association between reproductive history, lifestyle/ dietary habits, tobacco and alcohol exposures, family history in relation to cancer and inheritable diseases was assessed by univariate lo-gistic regression using Chi-square tests and multivariate analyses using Cox regression. Results: Age at diagnosis was highest between 41 to 50 years. Consumption of fermented pork fat, smoked food and Smoke-less tobacco, lower intake of vegetables/ water, having a first/ or second de-gree relative with cancers and inheritable diseases were found to be the major risk factors. Certain known factors were also acting as confounding factors. Conclusions: The present study reveals that Mizo women with first- and second-degree relatives of breast cancer, various other cancers and inheritable diseases have increased risk of breast cancer. This study also highlights the importance of analysing genetic factors which can aid in early detection of in-herited risk factors.en_US
dc.identifier.affiliationsMizoram University, Mizoram, Indiaen_US
dc.identifier.affiliationsMizoram State Cancer Institute, Mizoram, Indiaen_US
dc.identifier.affiliationsAdvanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, Indiaen_US
dc.identifier.citationZodinpuii D, Pautu JL, Zothankima B, Khenglawt L, Lallawmzuali D, Lalmuanpuii R, zuali L, Ralte L, Muthukumaran RB, Varma AK, Zothanzama J, Senthil Kumar N.. Breast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast India . National Journal of Community Medicine. 2022 Sep; 13(9): 606-611en_US
dc.identifier.issn2229-6816
dc.identifier.issn0976-3325
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217316
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber9en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.55489/njcm.130920222120en_US
dc.subjectDietary habitsen_US
dc.subjectFamily historyen_US
dc.subjectInheritable diseaseen_US
dc.subjectLifestyle habitsen_US
dc.subjectSmoked and fermented fooden_US
dc.titleBreast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast Indiaen_US
dc.typeJournal Articleen_US
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