Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice.

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dc.contributor.authorBhartiya, Uma S
dc.contributor.authorJoseph, Lebana J
dc.contributor.authorRaut, Yogita S
dc.contributor.authorRao, Badanidiyoor S
dc.date.accessioned2013-02-11T04:53:08Z
dc.date.available2013-02-11T04:53:08Z
dc.date.issued2010-06
dc.description.abstractSignificant increase in the salivary gland weight was observed after exposure to single therapeutic dose of 3.7 MBq of 131I in mice. Pre-supplementation of antioxidants, O. sanctum leaf extract, turmeric extract and vitamin E for 15 days before 131I exposure demonstrated significant reduction in the salivary gland weight. No major histopathological changes were observed in the salivary gland of experimental animals at 24 h of exposure. Micronuclei index in the bone marrow of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained unchanged in all the experimental groups. However, PCE/NCE ratio in the bone marrow decreased significantly in all the 131I exposed animals irrespective of antioxidant supplementation status. The normalization of salivary gland weight by antioxidant pre-supplementation in radioiodine exposed mice is suggestive of the possible ameliorating effect of antioxidants on the salivary gland weight recommending further detailed studies regarding the functional aspect of the salivary gland in higher animals.en_US
dc.identifier.citationBhartiya Uma S, Joseph Lebana J, Raut Yogita S, Rao Badanidiyoor S. Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. Indian Journal of Experimental Biology. 2010 June; 48(6): 566-571.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145008
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/9075en_US
dc.subjectAntioxidantsen_US
dc.subjectBone marrowen_US
dc.subjectRadioiodineen_US
dc.subjectSalivary glandsen_US
dc.titleEffect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice.en_US
dc.typeArticleen_US
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