Laboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017)

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dc.contributor.authorJoshi, Pen_US
dc.contributor.authorYadav, Pen_US
dc.contributor.authorMourya, Den_US
dc.contributor.authorSahare, Len_US
dc.contributor.authorUkey, Men_US
dc.contributor.authorKhedekar, Ren_US
dc.contributor.authorPatil, Den_US
dc.contributor.authorBarde, PVen_US
dc.date.accessioned2020-04-10T01:45:13Z
dc.date.available2020-04-10T01:45:13Z
dc.date.issued2020-01
dc.description.abstractBackground & objectives: Chikungunya (CHIK) is a neglected, re-emerging arboviral disease. Limited information on CHIK-confirmed cases during interepidemic period is available from India. This surveillance study was conducted in Madhya Pradesh (MP), India, during the years 2016-2017, to provide information about CHIK cases. Methods: Blood samples collected from patients suspected having CHIK were tested by immunoglobulin (Ig) IgM ELISA or real time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of CHIK virus (CHIKV)-specific IgM antibodies or viral RNA, respectively. Partial envelope-1 gene sequencing was done. Clinical and demographic data were collected and analyzed. Results: Of the 4019 samples tested, 494 (12.2%) were found positive for CHIKV infection. The positivity was detected in both rural and urban areas. The mean age of CHIK-positive cases was 33.12�.25 yr. Headache and joint pain were the most prominent symptoms, 34.6 per cent (171/494) of the CHIK cases required hospitalization and six patients with CHIKV infection died. The East/Central/South African genotype of CHIKV was found to be circulating in the study area. Interpretation & conclusions: Our study recorded a higher CHIK positivity during 2016-2017 in comparison to earlier reports from MP, India. A high proportion of CHIK cases required hospitalization and deaths were also reported, which indicated the severity of the disease in the study area. In-depth molecular analysis of the virus and other risk factors is essential to understand the trends in disease severity.en_US
dc.identifier.affiliationsDivision of Virology and Zoonoses, ICMR-National Institute of Research in Tribal Health, Jabalpur, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsMaximum Containment Laboratory, ICMR-National Institute of Virology, Pune, Maharashtra, Indiaen_US
dc.identifier.citationJoshi P, Yadav P, Mourya D, Sahare L, Ukey M, Khedekar R, Patil D, Barde PV. Laboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017). Indian Journal of Medical Research. 2020 Jan; 151(1): 87-92en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196108
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber1en_US
dc.relation.volume151en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_204_19en_US
dc.subjectChikungunyaen_US
dc.subjectCHIKVen_US
dc.subjectepidemiologyen_US
dc.subjectgenotypeen_US
dc.subjectseverityen_US
dc.titleLaboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017)en_US
dc.typeJournal Articleen_US
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