Laboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017)

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Date
2020-01
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Indian Council of Medical Research
Abstract
Background & objectives: Chikungunya (CHIK) is a neglected, re-emerging arboviral disease. Limited information on CHIK-confirmed cases during interepidemic period is available from India. This surveillance study was conducted in Madhya Pradesh (MP), India, during the years 2016-2017, to provide information about CHIK cases. Methods: Blood samples collected from patients suspected having CHIK were tested by immunoglobulin (Ig) IgM ELISA or real time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of CHIK virus (CHIKV)-specific IgM antibodies or viral RNA, respectively. Partial envelope-1 gene sequencing was done. Clinical and demographic data were collected and analyzed. Results: Of the 4019 samples tested, 494 (12.2%) were found positive for CHIKV infection. The positivity was detected in both rural and urban areas. The mean age of CHIK-positive cases was 33.12�.25 yr. Headache and joint pain were the most prominent symptoms, 34.6 per cent (171/494) of the CHIK cases required hospitalization and six patients with CHIKV infection died. The East/Central/South African genotype of CHIKV was found to be circulating in the study area. Interpretation & conclusions: Our study recorded a higher CHIK positivity during 2016-2017 in comparison to earlier reports from MP, India. A high proportion of CHIK cases required hospitalization and deaths were also reported, which indicated the severity of the disease in the study area. In-depth molecular analysis of the virus and other risk factors is essential to understand the trends in disease severity.
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Keywords
Chikungunya, CHIKV, epidemiology, genotype, severity
Citation
Joshi P, Yadav P, Mourya D, Sahare L, Ukey M, Khedekar R, Patil D, Barde PV. Laboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017). Indian Journal of Medical Research. 2020 Jan; 151(1): 87-92
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https://imsear.searo.who.int/handle/123456789/196108
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Indian Journal of Medical Research