Anti-inflammatory and Xanthine Oxidase Inhibition Activities of Santolina chamaecyparissus Extracts

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dc.contributor.authorDjarmouni, Meriemen_US
dc.contributor.authorBaghiani, Abderrahmaneen_US
dc.contributor.authorAdjadj, Moufidaen_US
dc.contributor.authorArrar, Lekhmicien_US
dc.date.accessioned2019-12-06T09:17:12Z
dc.date.available2019-12-06T09:17:12Z
dc.date.issued2018-01
dc.description.abstractS. chamaecyparissus aerial parts were extracted with solvent of varying polarity: crude extract (CrE) chloroform extract (CHE), ethyl acetate extract (EAE), and aqueous extract (AE). The content of total phenolics, and flavonoids in all the extracts were determined with spectrophotometric methods. Among all the extracts analyzed, the EAE exhibited a higher phenolic and flavonoids content than other samples: 373.83 ± 0.23 mg gallic acid equivalent and 7.86 ± 61.51 mg quercetin equivalent/g of dried weigh, respectively. CHE and EAE, showed a high inhibition of xanthine oxidase (XO) P>0.05 with IC50(concentration inhibitory of 50% of XO activity): (0.051± 0.0002 mg/ml) and (0.052±0.0003 mg/ml) respectively, followed by CrE (0.091±0.001 mg/ml). The inhibition of xanthine oxidase by CHE and EAE showed a less efficient than allopurinol (IC50 = 0.0082 ± 0.0005 mg/ml). The CrE clearly demonstrated anti-inflammatory effects by reduced ear edema induced by PMA with 61.51%.   Our results indicate that EAE possesses potent antioxidant and CE noticed anti-inflammatory properties, and might be valuable natural source that could be applicable to both the medical and food industries.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Nature and Life Sciences. Ferhat Abbas University Setif-1, 19000 Setif, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Nature and Life Sciences. Ferhat Abbas University Setif-1, 19000 Setif, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Nature and Life Sciences. Ferhat Abbas University Setif-1, 19000 Setif, Algeria.en_US
dc.identifier.affiliationsLaboratory of Applied Biochemistry, Faculty of Nature and Life Sciences. Ferhat Abbas University Setif-1, 19000 Setif, Algeria.en_US
dc.identifier.citationDjarmouni Meriem, Baghiani Abderrahmane, Adjadj Moufida, Arrar Lekhmici. Anti-inflammatory and Xanthine Oxidase Inhibition Activities of Santolina chamaecyparissus Extracts. Annual Research & Review in Biology. 2018 Jan; 22(6): 1-7en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187744
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber6en_US
dc.relation.volume22en_US
dc.source.urihttps://doi.org/10.9734/ARRB/2018/39084en_US
dc.subjectSantolina chamaecyparissusen_US
dc.subjectxanthine oxidaseen_US
dc.subjectantiinflammatoryen_US
dc.subjectphenolicsen_US
dc.titleAnti-inflammatory and Xanthine Oxidase Inhibition Activities of Santolina chamaecyparissus Extractsen_US
dc.typeJournal Articleen_US
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